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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Gastrula

 
 
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Disease relevance of Gastrula

 

High impact information on Gastrula

  • Extracellular levels of Sizzled and Chordin in the gastrula embryo and enzyme reaction constants were all in the 10(-8) M range, consistent with a physiological role in the regulation of dorsal-ventral patterning [3].
  • Members of the bone morphogenetic protein (BMP) family actively promote ventral cell fates, such as epidermis and blood, in the vertebrate gastrula [4].
  • Smad2 signals serve to restrict the site of primitive streak formation and establish anterior-posterior identity within the epiblast [5].
  • Following ubiquitous maternal and zygotic expression, highest levels of oep mRNA are found in the gastrula margin and in axial structures and forebrain [6].
  • We have isolated two Xenopus relatives of murine Sox17 expressed in gastrula presumptive endoderm [7].
 

Biological context of Gastrula

 

Anatomical context of Gastrula

 

Associations of Gastrula with chemical compounds

  • Inhibition of mRNA transcription with actinomycin D shows that the epidermal antigen is certainly transcribed by the late gastrula stage (stage 12) [18].
  • The oocyte-type tyrosine tRNA precursors are present in oocytes, very abundant in gastrula embryos, but absent from postembryonic somatic cells [19].
  • At gastrula stage Sp88 transcripts are almost completely confined to the nucleus [Lev, Z., Thomas, T. L., Lee, A. S., Angerer, R. C., Britten, R. J. & Davidson, E. H. (1980) Dev. Biol, 75, in press] [20].
  • No benzidine-positive cells or beta H1-globin mRNA expression was detected at the primitive streak or neural plate stage of development (E7.5) [21].
  • Treatment of late blastula/early gastrula stage Xenopus embryos with all-trans retinoic acid results in disruption of the primary body axis through effects on both mesoderm and neuroectoderm [22].
 

Gene context of Gastrula

 

Analytical, diagnostic and therapeutic context of Gastrula

References

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