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Gene Review

NKX2-5  -  NK2 transcription factor related, locus 5...

Gallus gallus

Synonyms: CNKX-2.5, NKX-2.5
 
 
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High impact information on NKX2-5

  • By contrast, overexpression of a human NKX2-5 mutant did not effect these markers in vivo or in vitro, suggesting one possible mechanism for clinical phenotypes [1].
  • Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression [1].
  • Overexpression of Nkx2-5 caused inhibition of slow tonic myosin heavy chain protein (sMHC), a late Purkinje fiber marker but did not affect Cx40 levels [1].
  • BMP-2 was able to induce Nkx2-5 expression ectopically within the anterior head domain, while GATA-4 was also induced more caudally [2].
  • While cNkx2-8 expression partially overlaps with other NK genes, such as Nkx2-5 and Nkx2-3, its onset and aspects of its expression domains are specific [3].

References

  1. Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression. Harris, B.S., Spruill, L., Edmonson, A.M., Rackley, M.S., Benson, D.W., O'Brien, T.X., Gourdie, R.G. Dev. Dyn. (2006) [Pubmed]
  2. BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos. Andrée, B., Duprez, D., Vorbusch, B., Arnold, H.H., Brand, T. Mech. Dev. (1998) [Pubmed]
  3. Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development. Brand, T., Andrée, B., Schneider, A., Buchberger, A., Arnold, H.H. Mech. Dev. (1997) [Pubmed]
 
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