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nkx2.5  -  NK2 homeobox 5

Danio rerio

Synonyms: SO:0000704, nk2.5, nkx2-5, zgc:111912
 
 
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High impact information on nkx2.5

  • Together, these results implicate zebrafish Gata5 in controlling the growth, morphogenesis, and differentiation of the heart and endoderm and indicate that Gata5 regulates the expression of the early myocardial gene nkx2.5 [1].
  • Forced expression of gata5 in swr/bmp2b and Zoep mutants restores robust nkx2.5 expression [2].
  • Embryos lacking zygotic oep (Zoep mutants) display cardia bifida and, as we show here, also display reduced or absent nkx2.5 expression [2].
  • Recently, we have demonstrated that the zinc finger transcription factor Gata5 is an essential regulator of nkx2.5 expression [2].
  • The preeminence of nkx2.7 in these embryonic lineages is consistent with a key role in cell fate determination, perhaps in part through the induction of nkx2.5 and nkx2 [3].
 

Anatomical context of nkx2.5

  • As an indicator of cardiac induction, we examine expression of nkx2.5, the earliest known marker of precardiac mesoderm; to assess anterior-posterior patterning, we distinguish ventricle from atrium with antibodies that recognize different myosin heavy chain isoforms [4].
 

Regulatory relationships of nkx2.5

  • We conclude that Bmp2b and Oep function at least partly through Gata5 to regulate nkx2.5 expression and promote myocardial differentiation [2].

References

  1. Gata5 is required for the development of the heart and endoderm in zebrafish. Reiter, J.F., Alexander, J., Rodaway, A., Yelon, D., Patient, R., Holder, N., Stainier, D.Y. Genes Dev. (1999) [Pubmed]
  2. Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5. Reiter, J.F., Verkade, H., Stainier, D.Y. Dev. Biol. (2001) [Pubmed]
  3. A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Lee, K.H., Xu, Q., Breitbart, R.E. Dev. Biol. (1996) [Pubmed]
  4. Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning. Alexander, J., Stainier, D.Y., Yelon, D. Dev. Genet. (1998) [Pubmed]
 
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