The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GATA4  -  GATA binding protein 4

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on GATA4

  • BMPs apparently function, in part, by affecting the levels of the GATA4 transcription factor, and work in parallel to FGF signaling from the cardiac mesoderm [1].
  • By systematic mutagenesis and gel shift analysis of this enhancer, we demonstrate that GATA4/5/6, YY1 and SMAD1/4 are all necessary for BMP-mediated induction and heart-specific expression of CAR3 [2].
  • SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer [2].
  • Moreover, Y27632 induced precocious expression of cardiac alpha-actin, an early marker of cardiomyocyte differentiation, coincident with the upregulated expression of serum response factor and GATA4 [3].
  • BMP-2 was able to induce Nkx2-5 expression ectopically within the anterior head domain, while GATA-4 was also induced more caudally [4].

Biological context of GATA4


Anatomical context of GATA4

  • Cardia bifida is known to occur in animal models lacking the cardiogenic transcriptional factor GATA-4 [5].
  • Treatment with small interfering RNAs (siRNA) specifically targeting GATA-4 into cardiac mesodermal cells led to the development of cardia bifida in chick embryos [5].
  • In addition, ES + CM co-culture activated crucial transcription factors (sox 17alpha, HNF3beta, and GATA 4) required for hepatocyte development by day 1. mRNA for albumin and especially a-fetoprotein were also increased by culture days 2 and 4 [7].


  1. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Rossi, J.M., Dunn, N.R., Hogan, B.L., Zaret, K.S. Genes Dev. (2001) [Pubmed]
  2. SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. Lee, K.H., Evans, S., Ruan, T.Y., Lassar, A.B. Development (2004) [Pubmed]
  3. Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Wei, L., Roberts, W., Wang, L., Yamada, M., Zhang, S., Zhao, Z., Rivkees, S.A., Schwartz, R.J., Imanaka-Yoshida, K. Development (2001) [Pubmed]
  4. BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos. Andrée, B., Duprez, D., Vorbusch, B., Arnold, H.H., Brand, T. Mech. Dev. (1998) [Pubmed]
  5. GATA-4 regulates cardiac morphogenesis through transactivation of the N-cadherin gene. Zhang, H., Toyofuku, T., Kamei, J., Hori, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  6. Profiles of mRNA expression of genes related to sex differentiation of the gonads in the chicken embryo. Yamamoto, I., Tsukada, A., Saito, N., Shimada, K. Poult. Sci. (2003) [Pubmed]
  7. Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm. Fair, J.H., Cairns, B.A., Lapaglia, M., Wang, J., Meyer, A.A., Kim, H., Hatada, S., Smithies, O., Pevny, L. Surgery (2003) [Pubmed]
WikiGenes - Universities