The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

MYBL2  -  v-myb avian myeloblastosis viral oncogene...

Gallus gallus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on MYBL2

  • Disruption of B-myb in DT40 cells reveals novel function for B-Myb in the response to DNA-damage [1].
  • A large body of evidence suggests that B-Myb plays an important role in cell cycle regulation; however, the exact nature of its function has not yet been clarified [1].
  • We find that the cells proliferate well in the absence of B-Myb, suggesting that B-Myb is not essential for cell proliferation per se [1].
  • Finally, we show that the HSP70 promoter is activated in a Myb binding site independent fashion not only by v-Myb, but also by chicken c-Myb and chicken B-Myb [2].
  • Since chicken B-Myb has been shown previously to be unable to transactivate a Myb binding-site containing promoter, such as the mim-1 promoter (Foos et al., 1992), our results also show that both modes of transactivation are independent of each other [2].
 

Biological context of MYBL2

  • Solution structure of the B-Myb DNA-binding domain: a possible role for conformational instability of the protein in DNA binding and control of gene expression [3].

References

  1. Disruption of B-myb in DT40 cells reveals novel function for B-Myb in the response to DNA-damage. Ahlbory, D., Appl, H., Lang, D., Klempnauer, K.H. Oncogene (2005) [Pubmed]
  2. TATA-box dependent trans-activation of the human HSP70 promoter by Myb proteins. Foos, G., Natour, S., Klempnauer, K.H. Oncogene (1993) [Pubmed]
  3. Solution structure of the B-Myb DNA-binding domain: a possible role for conformational instability of the protein in DNA binding and control of gene expression. McIntosh, P.B., Frenkiel, T.A., Wollborn, U., McCormick, J.E., Klempnauer, K.H., Feeney, J., Carr, M.D. Biochemistry (1998) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities