Gene Review:
MYBL2 - v-myb avian myeloblastosis viral oncogene...
Homo sapiens
Synonyms:
B-MYB, B-Myb, BMYB, Myb-like protein 2, Myb-related protein B
- Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft. Bar-Shira, A., Pinthus, J.H., Rozovsky, U., Goldstein, M., Sellers, W.R., Yaron, Y., Eshhar, Z., Orr-Urtreger, A. Cancer Res. (2002)
- Co-regulation of B-Myb expression by E2F1 and EGF receptor. Hanada, N., Lo, H.W., Day, C.P., Pan, Y., Nakajima, Y., Hung, M.C. Mol. Carcinog. (2006)
- Redundant functions of B-Myb and c-Myb in differentiating myeloid cells. Golay, J., Broccoli, V., Borleri, G.M., Erba, E., Faretta, M., Basilico, L., Ying, G.G., Piccinini, G., Shapiro, L.H., Lovrić, J., Nawrath, M., Mölling, K., Rambaldi, A., Introna, M. Cell Growth Differ. (1997)
- The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Radkov, S.A., Kellam, P., Boshoff, C. Nat. Med. (2000)
- HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes. Lam, E.W., Morris, J.D., Davies, R., Crook, T., Watson, R.J., Vousden, K.H. EMBO J. (1994)
- A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Shepard, J.L., Amatruda, J.F., Stern, H.M., Subramanian, A., Finkelstein, D., Ziai, J., Finley, K.R., Pfaff, K.L., Hersey, C., Zhou, Y., Barut, B., Freedman, M., Lee, C., Spitsbergen, J., Neuberg, D., Weber, G., Golub, T.R., Glickman, J.N., Kutok, J.L., Aster, J.C., Zon, L.I. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest. Lin, D., Fiscella, M., O'Connor, P.M., Jackman, J., Chen, M., Luo, L.L., Sala, A., Travali, S., Appella, E., Mercer, W.E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Li, X., McDonnell, D.P. Mol. Cell. Biol. (2002)
- Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. Noben-Trauth, K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Sonoda, G., Testa, J.R., Klempnauer, K.H. Genomics (1996)
- Functional domains of the human B-myb gene product. Nakagoshi, H., Takemoto, Y., Ishii, S. J. Biol. Chem. (1993)
- The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain. Joaquin, M., Watson, R.J. J. Biol. Chem. (2003)
- B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain. Petrovas, C., Jeay, S., Lewis, R.E., Sonenshein, G.E. Oncogene (2003)
- Transcriptional regulation of the murine surfactant protein-A gene by B-Myb. Bruno, M.D., Whitsett, J.A., Ross, G.F., Korfhagen, T.R. J. Biol. Chem. (1999)
- Effects of B-Myb on gene transcription: phosphorylation-dependent activity ans acetylation by p300. Johnson, L.R., Johnson, T.K., Desler, M., Luster, T.A., Nowling, T., Lewis, R.E., Rizzino, A. J. Biol. Chem. (2002)
- c-Myb trans-activates the human DNA topoisomerase IIalpha gene promoter. Brandt, T.L., Fraser, D.J., Leal, S., Halandras, P.M., Kroll, A.R., Kroll, D.J. J. Biol. Chem. (1997)
- Phosphorylation of B-Myb regulates its transactivation potential and DNA binding. Johnson, T.K., Schweppe, R.E., Septer, J., Lewis, R.E. J. Biol. Chem. (1999)
- c-Myb repression of c-erbB-2 transcription by direct binding to the c-erbB-2 promoter. Mizuguchi, G., Kanei-Ishii, C., Takahashi, T., Yasukawa, T., Nagase, T., Horikoshi, M., Yamamoto, T., Ishii, S. J. Biol. Chem. (1995)
- The highly conserved DNA-binding domains of A-, B- and c-Myb differ with respect to DNA-binding, phosphorylation and redox properties. Bergholtz, S., Andersen , T.O., Andersson, K.B., Borrebaek, J., Lüscher, B., Gabrielsen, O.S. Nucleic Acids Res. (2001)
- Expression of a thioredoxin-related protein-1 is induced by prostaglandin E(2). Kim, K.Y., Lee, J.W., Park, M.S., Jung, M.H., Jeon, G.A., Nam, M.J. Int. J. Cancer (2006)
- B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107. Joaquin, M., Bessa, M., Saville, M.K., Watson, R.J. Oncogene (2002)
- The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. Saville, M.K., Watson, R.J. Oncogene (1998)
- B-Myb and cyclin D1 mediate heat shock element dependent activation of the human HSP70 promoter. Kamano, H., Klempnauer, K.H. Oncogene (1997)
- B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts. Cicchillitti, L., Jimenez, S.A., Sala, A., Saitta, B. Biochem. J. (2004)
- Change in gene expression profile induced by alpha-melanocyte stimulating hormone in a malignant mesothelioma cell line. Colombo, G., Sordi, A., Turcatti, F., Carlin, A., Rossi, C., Lonati, C., Santambrogio, L., Gatti, S., Catania, A. Cell. Mol. Biol. (Noisy-le-grand) (2006)
- Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway. Charrasse, S., Carena, I., Brondani, V., Klempnauer, K.H., Ferrari, S. Oncogene (2000)
- Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. Bartsch, O., Horstmann, S., Toprak, K., Klempnauer, K.H., Ferrari, S. Eur. J. Biochem. (1999)
- Prognosis and gene expression profiling of 20q13-amplified breast cancers. Ginestier, C., Cervera, N., Finetti, P., Esteyries, S., Esterni, B., Adélaïde, J., Xerri, L., Viens, P., Jacquemier, J., Charafe-Jauffret, E., Chaffanet, M., Birnbaum, D., Bertucci, F. Clin. Cancer Res. (2006)
- Myb binding sites mediate negative regulation of c-myb expression in T-cell lines. Guerra, J., Withers, D.A., Boxer, L.M. Blood (1995)
- B-myb proto-oncogene products interact in vivo with each other via the carboxy-terminal conserved region. Kim, T., Jung, H., Min, S., Kim, K.T., Ha, H. FEBS Lett. (1999)