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Gene Review

CCND1  -  cyclin D1

Gallus gallus

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High impact information on CCND1

  • These results highlight an unexpected role for cyclin D as a CDK-independent repressor of transcriptional activation by v-Myb but not c-Myb [1].
  • The increase of DNA-synthesis is well correlated with the increased levels of cyclin D1 and cdk4 that control the G1 phase, and also with the activities of cell-cycle proteins involved in the G1 to S phase progression, such as cyclin E/A-cdk2 complexes [2].
  • Hence, our data show that the canonical Wnt signaling cascade directly regulates the NRSF/REST and Cyclin D1 genes, thereby controlling the progenitor cells [3].


  1. D-type cyclins repress transcriptional activation by the v-Myb but not the c-Myb DNA-binding domain. Ganter, B., Fu, S., Lipsick, J.S. EMBO J. (1998) [Pubmed]
  2. Thyroid hormones regulate DNA-synthesis and cell-cycle proteins by activation of PKCalpha and p42/44 MAPK in chick embryo hepatocytes. Alisi, A., Spagnuolo, S., Napoletano, S., Spaziani, A., Leoni, S. J. Cell. Physiol. (2004) [Pubmed]
  3. The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord. Nishihara, S., Tsuda, L., Ogura, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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