The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CCNE1  -  cyclin E1

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on CCNE1

  • Hippo regulates bantam independently of cyclin E and diap1, two other Hippo targets, and overexpression of bantam mimics overgrowth phenotypes of hippo mutant cells [1].
  • The increase of DNA-synthesis is well correlated with the increased levels of cyclin D1 and cdk4 that control the G1 phase, and also with the activities of cell-cycle proteins involved in the G1 to S phase progression, such as cyclin E/A-cdk2 complexes [2].

Other interactions of CCNE1

  • Moreover, EGF increased the CDK-2, CDK-4, cyclin D1, and cyclin E expression levels but decreased the p21 and p27 expression levels [3].


  1. The bantam MicroRNA Is a Target of the Hippo Tumor-Suppressor Pathway. Nolo, R., Morrison, C.M., Tao, C., Zhang, X., Halder, G. Curr. Biol. (2006) [Pubmed]
  2. Thyroid hormones regulate DNA-synthesis and cell-cycle proteins by activation of PKCalpha and p42/44 MAPK in chick embryo hepatocytes. Alisi, A., Spagnuolo, S., Napoletano, S., Spaziani, A., Leoni, S. J. Cell. Physiol. (2004) [Pubmed]
  3. Effect of EGF on [(3)H]-thymidine incorporation and cell cycle regulatory proteins in primary cultured chicken hepatocytes: Involvement of Ca(2+)/PKC and MAPKs. Lee, M.Y., Lee, S.H., Kim, Y.H., Heo, J.S., Park, S.H., Lee, J.H., Han, H.J. J. Cell. Biochem. (2006) [Pubmed]
WikiGenes - Universities