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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CCNE1  -  cyclin E1

Gallus gallus

 
 
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High impact information on CCNE1

  • Hippo regulates bantam independently of cyclin E and diap1, two other Hippo targets, and overexpression of bantam mimics overgrowth phenotypes of hippo mutant cells [1].
  • The increase of DNA-synthesis is well correlated with the increased levels of cyclin D1 and cdk4 that control the G1 phase, and also with the activities of cell-cycle proteins involved in the G1 to S phase progression, such as cyclin E/A-cdk2 complexes [2].
 

Other interactions of CCNE1

  • Moreover, EGF increased the CDK-2, CDK-4, cyclin D1, and cyclin E expression levels but decreased the p21 and p27 expression levels [3].

References

  1. The bantam MicroRNA Is a Target of the Hippo Tumor-Suppressor Pathway. Nolo, R., Morrison, C.M., Tao, C., Zhang, X., Halder, G. Curr. Biol. (2006) [Pubmed]
  2. Thyroid hormones regulate DNA-synthesis and cell-cycle proteins by activation of PKCalpha and p42/44 MAPK in chick embryo hepatocytes. Alisi, A., Spagnuolo, S., Napoletano, S., Spaziani, A., Leoni, S. J. Cell. Physiol. (2004) [Pubmed]
  3. Effect of EGF on [(3)H]-thymidine incorporation and cell cycle regulatory proteins in primary cultured chicken hepatocytes: Involvement of Ca(2+)/PKC and MAPKs. Lee, M.Y., Lee, S.H., Kim, Y.H., Heo, J.S., Park, S.H., Lee, J.H., Han, H.J. J. Cell. Biochem. (2006) [Pubmed]
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