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Gene Review:

LCN8 - lipocalin 8

Gallus gallus

Synonyms: EX-FABP, EXFABP, P20K

Mao, P.L. et al., Descalzi Cancedda, F. et al., Bédard, P.A. et al., Bedard, P.A. et al.

Descalzi Cancedda, Dozin, Zerega, Cermelli, Cancedda,

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Disease relevance of P20K

Repression of quiescence-specific polypeptides in chicken heart mesenchymal cells transformed by Rous sarcoma virus [1].

High impact information on P20K

Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src [2].
We described the synthesis of a quiescence-specific p20K protein in quiescent chicken heart mesenchymal cells and contact-inhibited chicken embryo fibroblasts (Bédard, P.-A., Balk, S.D., Gunther, H.S., Morisi, A., and Erikson, R.L. (1987a) Mol. Cell. Biol. 7, 1450-1459) [3].
In developing chicken embryo long bones, Ex-FABP first appears at the boundary of the cone of hypertrophic cartilage. 'In vitro' EX-FABP is highly expressed by differentiating hypertrophic chondrocytes [4].

References

Repression of quiescence-specific polypeptides in chicken heart mesenchymal cells transformed by Rous sarcoma virus. Bédard, P.A., Balk, S.D., Gunther, H.S., Morisi, A., Erikson, R.L. Mol. Cell. Biol. (1987) [Pubmed]
Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src. Bedard, P.A., Yannoni, Y., Simmons, D.L., Erikson, R.L. Mol. Cell. Biol. (1989) [Pubmed]
Quiescence-dependent activation of the p20K promoter in growth-arrested chicken embryo fibroblasts. Mao, P.L., Beauchemin, M., Bédard, P.A. J. Biol. Chem. (1993) [Pubmed]
Extracellular fatty acid binding protein (ex-FABP) is a stress protein expressed during chondrocyte and myoblast differentiation. Descalzi Cancedda, F., Dozin, B., Zerega, B., Cermelli, S., Cancedda, R. Osteoarthr. Cartil. (2001) [Pubmed]

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