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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MYL4  -  myosin, light chain 4, alkali; atrial,...

Gallus gallus

Synonyms: L23, MLC
 
 
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High impact information on MYL4

  • These results strongly indicate that Le is identical to L23 and that embryonic chicken skeletal, cardiac, and smooth muscles express a common embryo-specific myosin light chain [1].
  • When we examined myosins in developing chicken ventricular and pectoralis muscles by two-dimensional gel electrophoresis, the myosin light chain (Le) that completely comigrates with L23 was detected in both striated muscles at early developmental stages [1].
  • It has been demonstrated that embryonic chicken gizzard smooth muscle contains a unique embryonic myosin light chain of 23,000 mol wt, called L23 (Katoh, N., and S. Kubo, 1978, Biochem. Biophys. Acta, 535:401-411; Takano-Ohmuro, H., T. Obinata, T. Mikawa, and T. Masaki, 1983, J. Biochem. (Tokyo), 93:903-908) [1].
  • The deduced amino acid sequence for L23 showed high sequence similarities to those of adult alkali type MLCs from various tissues, indicating that L23 belongs to the alkali MLC group [2].
  • A chick embryonic myosin alkali light chain L23 gene that is expressed transiently at embryonic stages in chick skeletal, cardiac and smooth muscles and in brain continuously from embryo to adult stages, was isolated and characterized [3].
 

Anatomical context of MYL4

  • We have isolated cDNA clones of the mRNA for chick embryonic myosin light chain (MLC), L23, by cross-hybridization with chicken skeletal muscle MLC1 cDNA [2].
 

Analytical, diagnostic and therapeutic context of MYL4

References

  1. Embryonic chicken skeletal, cardiac, and smooth muscles express a common embryo-specific myosin light chain. Takano-Ohmuro, H., Obinata, T., Kawashima, M., Masaki, T., Tanaka, T. J. Cell Biol. (1985) [Pubmed]
  2. A common myosin light chain is expressed in chicken embryonic skeletal, cardiac, and smooth muscles and in brain continuously from embryo to adult. Kawashima, M., Nabeshima, Y., Obinata, T., Fujii-Kuriyama, Y. J. Biol. Chem. (1987) [Pubmed]
  3. Isolation of the chick myosin alkali light chain gene expressed in embryonic gizzard muscle and transitional expression of the light chain gene family in vivo. Nabeshima, Y., Nabeshima, Y., Kawashima, M., Nakamura, S., Nonomura, Y., Fujii-Kuriyama, Y. J. Mol. Biol. (1988) [Pubmed]
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