Gene Review:
Myl4 - myosin, light polypeptide 4
Mus musculus
Synonyms:
ALC1, AMLC, ELC, ELC1a, GT1, ...
- A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene. Catala, F., Wanner, R., Barton, P., Cohen, A., Wright, W., Buckingham, M. Mol. Cell. Biol. (1995)
- Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. Kovoor, P., Wickman, K., Maguire, C.T., Pu, W., Gehrmann, J., Berul, C.I., Clapham, D.E. J. Am. Coll. Cardiol. (2001)
- Induction of atrial tachycardia and fibrillation in the mouse heart. Wakimoto, H., Maguire, C.T., Kovoor, P., Hammer, P.E., Gehrmann, J., Triedman, J.K., Berul, C.I. Cardiovasc. Res. (2001)
- Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A(3) adenosine receptors. Fabritz, L., Kirchhof, P., Fortmüller, L., Auchampach, J.A., Baba, H.A., Breithardt, G., Neumann, J., Boknik, P., Schmitz, W. Cardiovasc. Res. (2004)
- Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Pashmforoush, M., Lu, J.T., Chen, H., Amand, T.S., Kondo, R., Pradervand, S., Evans, S.M., Clark, B., Feramisco, J.R., Giles, W., Ho, S.Y., Benson, D.W., Silberbach, M., Shou, W., Chien, K.R. Cell (2004)
- Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Bamforth, S.D., Bragança, J., Eloranta, J.J., Murdoch, J.N., Marques, F.I., Kranc, K.R., Farza, H., Henderson, D.J., Hurst, H.C., Bhattacharya, S. Nat. Genet. (2001)
- Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases. Singh, S., Lowe, D.G., Thorpe, D.S., Rodriguez, H., Kuang, W.J., Dangott, L.J., Chinkers, M., Goeddel, D.V., Garbers, D.L. Nature (1988)
- Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Arch, J.R., Ainsworth, A.T., Cawthorne, M.A., Piercy, V., Sennitt, M.V., Thody, V.E., Wilson, C., Wilson, S. Nature (1984)
- Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Milano, C.A., Allen, L.F., Rockman, H.A., Dolber, P.C., McMinn, T.R., Chien, K.R., Johnson, T.D., Bond, R.A., Lefkowitz, R.J. Science (1994)
- In vivo cardiac electrophysiology studies in the mouse. Berul, C.I., Aronovitz, M.J., Wang, P.J., Mendelsohn, M.E. Circulation (1996)
- Antiarrhythmic activity of p-hydroxy-N-(2-diethylaminoethyl) benzamide (the p-hydroxy isostere of procainamide) in dogs and mice. Drayer, D.E., Slaven, B.H., Reidenberg, M.M., Bagwell, E.E., Cordova, M. J. Med. Chem. (1977)
- Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice. Pawloski-Dahm, C.M., Song, G., Kirkpatrick, D.L., Palermo, J., Gulick, J., Dorn, G.W., Robbins, J., Walsh, R.A. Circulation (1998)
- The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Lee, Y., Shioi, T., Kasahara, H., Jobe, S.M., Wiese, R.J., Markham, B.E., Izumo, S. Mol. Cell. Biol. (1998)
- Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. Kuo, H., Chen, J., Ruiz-Lozano, P., Zou, Y., Nemer, M., Chien, K.R. Development (1999)
- Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos. Gruber, P.J., Kubalak, S.W., Chien, K.R. Development (1998)
- Cardiomyocytes can be generated from marrow stromal cells in vitro. Makino, S., Fukuda, K., Miyoshi, S., Konishi, F., Kodama, H., Pan, J., Sano, M., Takahashi, T., Hori, S., Abe, H., Hata, J., Umezawa, A., Ogawa, S. J. Clin. Invest. (1999)
- Developmental regulation of myosin gene expression in mouse cardiac muscle. Lyons, G.E., Schiaffino, S., Sassoon, D., Barton, P., Buckingham, M. J. Cell Biol. (1990)
- Myosin light chain gene expression in developing and denervated fetal muscle in the mouse. Barton, P.J., Harris, A.J., Buckingham, M.E. Development (1989)
- Structure and sequence of the myosin alkali light chain gene expressed in adult cardiac atria and fetal striated muscle. Barton, P.J., Robert, B., Cohen, A., Garner, I., Sassoon, D., Weydert, A., Buckingham, M.E. J. Biol. Chem. (1988)
- Fetal cardiac natriuretic peptide expression and cardiovascular hemodynamics in endotoxin-induced acute cardiac dysfunction in mouse. Mäkikallio, K., Rounioja, S., Vuolteenaho, O., Paakkari, J., Hallman, M., Räsänen, J. Pediatr. Res. (2006)
- Gene expression of phenylethanolamine N-methyltransferase in corticotropin-releasing hormone knockout mice during stress exposure. Kvetnansky, R., Kubovcakova, L., Tillinger, A., Micutkova, L., Krizanova, O., Sabban, E.L. Cell. Mol. Neurobiol. (2006)
- Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. Dyson, E., Sucov, H.M., Kubalak, S.W., Schmid-Schönbein, G.W., DeLano, F.A., Evans, R.M., Ross, J., Chien, K.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator. Laumen, H., Brunner, C., Greiner, A., Wirth, T. Nucleic Acids Res. (2004)
- The expression of myosin genes in developing skeletal muscle in the mouse embryo. Lyons, G.E., Ontell, M., Cox, R., Sassoon, D., Buckingham, M. J. Cell Biol. (1990)
- Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles. Ontell, M., Ontell, M.P., Sopper, M.M., Mallonga, R., Lyons, G., Buckingham, M. Development (1993)
- Promoter analysis of myosin alkali light chain genes expressed in mouse striated muscle. Cohen, A., Barton, P.J., Robert, B., Garner, I., Alonso, S., Buckingham, M.E. Nucleic Acids Res. (1988)
- Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules. Chi, X., Chatterjee, P.K., Wilson, W., Zhang, S.X., Demayo, F.J., Schwartz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice. Fewell, J.G., Hewett, T.E., Sanbe, A., Klevitsky, R., Hayes, E., Warshaw, D., Maughan, D., Robbins, J. J. Clin. Invest. (1998)
- Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. Minamisawa, S., Wang, Y., Chen, J., Ishikawa, Y., Chien, K.R., Matsuoka, R. J. Biol. Chem. (2003)
- Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. Kubalak, S.W., Miller-Hance, W.C., O'Brien, T.X., Dyson, E., Chien, K.R. J. Biol. Chem. (1994)