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Gene Review:

THRA - thyroid hormone receptor, alpha

Sus scrofa

Sato, K. et al.

Sato, Yamazaki, Yamada, Kanaji, Miura, Obara,

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Disease relevance of THRA

The THRA induced by TBII(+)/TSAb(+) IgGs as well as TBII(-)/TSAb(-) IgG was inhibited by blocking-type TRAb obtained from TBII(+) patients with myxedema [1].
Seventy TBII(+)/TSAb( + )-, 3 TBII( + )/TSAb( - )-, and 3 TBII( - )/TSAb( + )- patients with untreated Graves' disease were all positive for THRA, which became undetectable in spontaneous remission obtained after several years of medical treatment [1].

High impact information on THRA

These in vitro findings suggest that all IgGs obtained from untreated Graves' patients (n = 78) elicit potent THRA in human thyroid follicles in suspension culture [1].

References

Immunoglobulins of untreated Graves' patients with or without thyrotropin receptor antibody (determined by porcine thyrocytes) universally elicit potent thyroid hormone-releasing activity in cultured human thyroid follicles. Sato, K., Yamazaki, K., Yamada, E., Kanaji, Y., Miura, M., Obara, T. Thyroid (1999) [Pubmed]

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