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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Arl1  -  ADP ribosylation factor-like 1

Drosophila melanogaster

Synonyms: 72CDd, ADP-ribosylation factor-like protein 1, ARL1, ARL1_DROME, Arf, ...
 
 
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High impact information on Arf72A

  • A recessive lethal arl mutation was recovered, demonstrating that the arl locus is an essential gene [1].
  • The use of RNAi, Arf72A mutant analysis and ectopic expression of the GRIP domain, shows that cycling of Cbs during mitosis is required for the centrosome cycle [2].
  • An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility [3].
  • Small GTPases of the Arf and Rab families play key roles in the function of subcellular organelles [3].
  • The similarities of sequence and biochemical properties between Drosophila and mammalian ARFs contrast with their differences from Drosophila arl (ARF-like protein), which does not stimulate cholera toxin-catalyzed ADP-ribosylation, and is only approximately 52-56% identical in amino acid sequence to mammalian ARFs [4].
 

Associations of Arf72A with chemical compounds

  • It has been assumed that much of this specificity will be defined by determining which regulators of Arfs, the GEFs (guanine nucleotide-exchange factors) and GAPs (GTPase-activating proteins) function with which Arf proteins [5].

References

  1. The arflike gene encodes an essential GTP-binding protein in Drosophila. Tamkun, J.W., Kahn, R.A., Kissinger, M., Brizuela, B.J., Rulka, C., Scott, M.P., Kennison, J.A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. centrosomin's beautiful sister (cbs) encodes a GRIP-domain protein that marks Golgi inheritance and functions in the centrosome cycle inDrosophila. Eisman, R.C., Stewart, N., Miller, D., Kaufman, T.C. J. Cell. Sci. (2006) [Pubmed]
  3. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. Hofmann, I., Munro, S. J. Cell. Sci. (2006) [Pubmed]
  4. Molecular characterization of a conserved, guanine nucleotide-dependent ADP-ribosylation factor in Drosophila melanogaster. Murtagh, J.J., Lee, F.J., Deak, P., Hall, L.M., Monaco, L., Lee, C.M., Stevens, L.A., Moss, J., Vaughan, M. Biochemistry (1993) [Pubmed]
  5. Localization and function of Arf family GTPases. Donaldson, J.G., Honda, A. Biochem. Soc. Trans. (2005) [Pubmed]
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