Gene Review:
TPM4 - tropomyosin 4
Sus scrofa
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Disease relevance of TPM4
- We also tested whether TM4 expression was correspondingly enhanced during atherogenesis [1].
High impact information on TPM4
- The present study demonstrates that upregulation of TM4 mRNA is a relevant marker of dedifferentiation in vascular SMC [1].
- Tropomyosin 4 expression is enhanced in dedifferentiating smooth muscle cells in vitro and during atherogenesis [1].
- We compared the localization patterns of myosin heavy chain isoforms in normal arteries and lesions of increasing severity and determined that TM4 expression was relegated mainly to SMC of the synthetic phenotype in the media and intima during atherogenesis [1].
- Induction of foam cell formation had no additional enhancing effect on the expression of TM4 in cultivated SMC [1].
Analytical, diagnostic and therapeutic context of TPM4
- The number of TM4-expressing SMC increased with plaque development as demonstrated by simultaneous in situ hybridization and immunohistochemistry [1].
References
- Tropomyosin 4 expression is enhanced in dedifferentiating smooth muscle cells in vitro and during atherogenesis. Abouhamed, M., Reichenberg, S., Robenek, H., Plenz, G. Eur. J. Cell Biol. (2003) [Pubmed]
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