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Gene Review:

not-a - notochord homeobox

Xenopus laevis

Synonyms: Xnot-2, Xnot2, Znot, flh, not, ...

Yasuo, H. et al., von Dassow, G. et al.

Yasuo, Lemaire,

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High impact information on LOC397961

We have studied the regulation of Xnot by signaling molecules involved in mesoderm induction and regionalization [1].
We describe the cloning and expression of Xnot, a novel homeo box-containing gene expressed primarily in the gastrula organizing region [1].
Gsc acts in deeper vegetal cells, where it regulates Frzb expression to maintain Xnot expression in the neighbouring notochord territory [2].

Anatomical context of LOC397961

Role of Goosecoid, Xnot and Wnt antagonists in the maintenance of the notochord genetic programme in Xenopus gastrulae [2].

References

Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. von Dassow, G., Schmidt, J.E., Kimelman, D. Genes Dev. (1993) [Pubmed]
Role of Goosecoid, Xnot and Wnt antagonists in the maintenance of the notochord genetic programme in Xenopus gastrulae. Yasuo, H., Lemaire, P. Development (2001) [Pubmed]

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