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Gene Review

hoxc6  -  homeobox C6

Xenopus laevis

Synonyms: Hoxc-6, xlhbox1
 
 
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High impact information on XlHbox1

  • In these, four position-specific neural markers (engrailed-2, Krox-20, XlHbox 1, and XlHbox 6) were expressed in the ectoderm in the same A-P order as in the embryo [1].
  • We show that the promoter of the dorsalizing homeo box gene siamois is a direct target for the beta-catenin/XTcf-3 complex, establishing a link between the Wnt pathway and the activation of genes involved in specifying the dorsal axis [2].
  • We describe the cloning and expression of Xnot, a novel homeo box-containing gene expressed primarily in the gastrula organizing region [3].
  • The results of these studies are consistent with the hypothesis that maternally derived signals from the Nieuwkoop center function to positively regulate expression of the homeo box gene goosecoid in Spemann organizer cells, leading to a subsequent repression of Xwnt-8 expression in these cells [4].
  • We have searched for homeo box-containing genes expressed during gastrulation in Xenopus embryos with the expectation that analysis of the spatial and temporal expression of these genes will lead to greater understanding of the regionalization of the mesoderm [3].
 

Biological context of XlHbox1

 

Anatomical context of XlHbox1

  • Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes [10].
  • XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm [11].
  • The XlHbox 8 homeodomain protein of Xenopus and STF-1, its mammalian homolog, are selectively expressed by beta cells of adult mouse pancreatic islets, where they are likely to regulate insulin expression [8].
  • When mesoderm-free vegetal explants (VEs) from early blastula stage embryos are cultured in isolation, XlHbox 8 expression develops autonomously in the dorsal region, strongly suggesting that endodermal region-specific determination occurs before MBT [12].
 

Other interactions of XlHbox1

 

Analytical, diagnostic and therapeutic context of XlHbox1

  • Studies on XlHbox 1 function show that the region common to the long and short proteins has a sequence-specific DNA-binding activity, and that microinjection of specific antibodies into embryos results in the loss of structures derived from cells normally expressing XlHbox 1 [14].
  • We have studied by immunohistofluorescence and confocal microscopy the localization of the XlHbox-1 protein, the product of a Xenopus class 1 homeobox gene corresponding to the human HOX 3C, during the development of Xenopus laevis mesodermal derivatives [9].

References

  1. Planar induction of anteroposterior pattern in the developing central nervous system of Xenopus laevis. Doniach, T., Phillips, C.R., Gerhart, J.C. Science (1992) [Pubmed]
  2. A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Brannon, M., Gomperts, M., Sumoy, L., Moon, R.T., Kimelman, D. Genes Dev. (1997) [Pubmed]
  3. Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. von Dassow, G., Schmidt, J.E., Kimelman, D. Genes Dev. (1993) [Pubmed]
  4. Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. Christian, J.L., Moon, R.T. Genes Dev. (1993) [Pubmed]
  5. Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Graham, A., Papalopulu, N., Lorimer, J., McVey, J.H., Tuddenham, E.G., Krumlauf, R. Genes Dev. (1988) [Pubmed]
  6. Sequential expression of murine homeo box genes during F9 EC cell differentiation. Breier, G., Bućan, M., Francke, U., Colberg-Poley, A.M., Gruss, P. EMBO J. (1986) [Pubmed]
  7. A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts. Wright, C.V., Cho, K.W., Fritz, A., Bürglin, T.R., De Robertis, E.M. EMBO J. (1987) [Pubmed]
  8. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Guz, Y., Montminy, M.R., Stein, R., Leonard, J., Gamer, L.W., Wright, C.V., Teitelman, G. Development (1995) [Pubmed]
  9. Changes in the prevalence of an homeobox gene product during muscle differentiation. Levi, G., Corsetti, M.T., Boncinelli, E., Corte, G. Mech. Dev. (1993) [Pubmed]
  10. Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes. Brown, B.D., Harland, R.M. Genes Dev. (1990) [Pubmed]
  11. XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Wright, C.V., Schnegelsberg, P., De Robertis, E.M. Development (1989) [Pubmed]
  12. Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8. Gamer, L.W., Wright, C.V. Dev. Biol. (1995) [Pubmed]
  13. The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Taira, M., Jamrich, M., Good, P.J., Dawid, I.B. Genes Dev. (1992) [Pubmed]
  14. Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity. Cho, K.W., Goetz, J., Wright, C.V., Fritz, A., Hardwicke, J., De Robertis, E.M. EMBO J. (1988) [Pubmed]
 
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