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Gene Review

ventx3.2  -  VENT homeobox 3, gene 2

Xenopus laevis

Synonyms: vex1, xvex-1
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High impact information on Xvex-1

  • Partial loss of Xvex-1 activity was able to improve the efficiency of secondary axis induction by the dominant negative BMP receptor or Smad6 [1].
  • The organizer genes, gsc and Otx-2, were identified as direct targets of Xvex-1 [1].
  • These observations together with the early widespread expression of Xvex-1 throughout the embryo prior to gastrulation encoding a homeodomain repressor protein, suggest that elements of the ventral signaling pathway play an important role during late blastula in restricting the formation of Spemann's organizer [1].

Anatomical context of Xvex-1

  • Expression of Xvex-1 during gastrula stages requires normal BMP-4 activity as evidenced from the injection of BMP-4, Smad1, Smad5 and Smad6 mRNA and antisense BMP-4 RNA [2].


  1. The Xvex-1 antimorph reveals the temporal competence for organizer formation and an early role for ventral homeobox genes. Shapira, E., Marom1, K., Levy, V., Yelin, R., Fainsod, A. Mech. Dev. (2000) [Pubmed]
  2. A role for the homeobox gene Xvex-1 as part of the BMP-4 ventral signaling pathway. Shapira, E., Marom, K., Yelin, R., Levy, A., Fainsod, A. Mech. Dev. (1999) [Pubmed]
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