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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Organizers, Embryonic

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High impact information on Organizers, Embryonic


Biological context of Organizers, Embryonic


Anatomical context of Organizers, Embryonic


Associations of Organizers, Embryonic with chemical compounds


Gene context of Organizers, Embryonic

  • In amphibians, Spemann's organizer, which is homologous to the node, partially overlaps with anterior endoderm cells expressing homologues of the AVE markers cerberus, Hex and Hesx1 [17].
  • To understand how integration of these different signaling pathways results in formation of Spemann's organizer, we sought to identify growth factor-responsive elements within the gsc promoter [18].
  • cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior nervous system [19].
  • Asymmetric expression of Sonic hedgehog (Shh) in Hensen's node of the chicken embryo plays a key role in the genetic cascade that controls left-right asymmetry, but its involvement in left-right specification in other vertebrates remains unclear [20].
  • Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos [21].

Analytical, diagnostic and therapeutic context of Organizers, Embryonic


  1. Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., Aizawa, S. Cell (2005) [Pubmed]
  2. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Leyns, L., Bouwmeester, T., Kim, S.H., Piccolo, S., De Robertis, E.M. Cell (1997) [Pubmed]
  3. Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Piccolo, S., Agius, E., Lu, B., Goodman, S., Dale, L., De Robertis, E.M. Cell (1997) [Pubmed]
  4. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Wang, S., Krinks, M., Lin, K., Luyten, F.P., Moos, M. Cell (1997) [Pubmed]
  5. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Piccolo, S., Sasai, Y., Lu, B., De Robertis, E.M. Cell (1996) [Pubmed]
  6. Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels. Yelin, R., Schyr, R.B., Kot, H., Zins, S., Frumkin, A., Pillemer, G., Fainsod, A. Dev. Biol. (2005) [Pubmed]
  7. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Bouwmeester, T., Kim, S., Sasai, Y., Lu, B., De Robertis, E.M. Nature (1996) [Pubmed]
  8. Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. Christian, J.L., Moon, R.T. Genes Dev. (1993) [Pubmed]
  9. Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. Jones, C.M., Dale, L., Hogan, B.L., Wright, C.V., Smith, J.C. Development (1996) [Pubmed]
  10. A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation. Streit, A., Stern, C.D., Théry, C., Ireland, G.W., Aparicio, S., Sharpe, M.J., Gherardi, E. Development (1995) [Pubmed]
  11. Digit induction by Hensen's node and notochord involves the expression of shh but not RAR-beta 2. Selleck, M.A., Hayamizu, T.F., Ohsugi, K., Bronner-Fraser, M., Bryant, S.V. Dev. Biol. (1996) [Pubmed]
  12. Evidence that Hensen's node is a site of retinoic acid synthesis. Hogan, B.L., Thaller, C., Eichele, G. Nature (1992) [Pubmed]
  13. Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo. Chen, Y., Huang, L., Russo, A.F., Solursh, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  14. Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Wei, L., Roberts, W., Wang, L., Yamada, M., Zhang, S., Zhao, Z., Rivkees, S.A., Schwartz, R.J., Imanaka-Yoshida, K. Development (2001) [Pubmed]
  15. Hensen's node from vitamin A-deficient quail embryo induces chick limb bud duplication and retains its normal asymmetric expression of Sonic hedgehog (Shh). Chen, Y., Dong, D., Kostetskii, I., Zile, M.H. Dev. Biol. (1996) [Pubmed]
  16. Suramin changes the fate of Spemann's organizer and prevents neural induction in Xenopus laevis. Grunz, H. Mech. Dev. (1992) [Pubmed]
  17. The organizer factors Chordin and Noggin are required for mouse forebrain development. Bachiller, D., Klingensmith, J., Kemp, C., Belo, J.A., Anderson, R.M., May, S.R., McMahon, J.A., McMahon, A.P., Harland, R.M., Rossant, J., De Robertis, E.M. Nature (2000) [Pubmed]
  18. Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Watabe, T., Kim, S., Candia, A., Rothbächer, U., Hashimoto, C., Inoue, K., Cho, K.W. Genes Dev. (1995) [Pubmed]
  19. cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior nervous system. Henrique, D., Tyler, D., Kintner, C., Heath, J.K., Lewis, J.H., Ish-Horowicz, D., Storey, K.G. Genes Dev. (1997) [Pubmed]
  20. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Tsukui, T., Capdevila, J., Tamura, K., Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallón, J., Chandraratna, R.A., Chien, K., Blumberg, B., Evans, R.M., Belmonte, J.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  21. Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. Reversade, B., Kuroda, H., Lee, H., Mays, A., De Robertis, E.M. Development (2005) [Pubmed]
  22. Molecular cloning and expression study of Xenopus latent TGF-beta binding protein-1 (LTBP-1). Quarto, N. Gene (2002) [Pubmed]
  23. Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos. Oelgeschläger, M., Kuroda, H., Reversade, B., De Robertis, E.M. Dev. Cell (2003) [Pubmed]
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