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Gene Review

ctbp2  -  C-terminal binding protein 2

Xenopus laevis

Synonyms: ctbp, ctbp-b
 
 
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High impact information on CtBP

  • We show that XTcf-3 contains amino- and carboxy-terminal repressor domains and have identified a Xenopus member of the C-terminal Binding Protein family of transcriptional co-repressors (XCtBP) as the C-terminal co-repressor [1].
  • Ectopic expression of XCtBP/G4A demonstrates that XCtBP functions in the regulation of head and notochord development [1].
  • We show that two XCtBP binding sites near the XTcf-3 carboxy-terminus are required for the interaction of XTcf-3 and XCtBP and for the transcriptional repression mediated by the XTcf-3 carboxy-terminal domain [1].
  • We show that the first zinc finger and CtBP interaction domains are required for this activity [2].

References

  1. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Brannon, M., Brown, J.D., Bates, R., Kimelman, D., Moon, R.T. Development (1999) [Pubmed]
  2. Evi1 is specifically expressed in the distal tubule and duct of the Xenopus pronephros and plays a role in its formation. Van Campenhout, C., Nichane, M., Antoniou, A., Pendeville, H., Bronchain, O.J., Marine, J.C., Mazabraud, A., Voz, M.L., Bellefroid, E.J. Dev. Biol. (2006) [Pubmed]
 
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