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Gene Review:

ABLIM1 - actin binding LIM protein 1

Homo sapiens

Synonyms: ABLIM, Actin-binding LIM protein 1, Actin-binding LIM protein family member 1, Actin-binding double zinc finger protein, KIAA0059, ...

Kim, A.C. et al., Klimov, E. et al.

Klimov, Rud'ko, Rakhmanaliev, Sulimova,

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High impact information on ABLIM1

Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers [1].
Interestingly, 10q25 is a region of frequent loss of heterozygosity in human tumors, thus identifying limatin as a candidate tumor suppressor gene [1].
Limatin was mapped to mouse Chromosome 19 by restriction fragment length polymorphism analysis and to human chromosome region 10q25 by fluorescence in situ hybridization [1].
The comparison of the amino acid sequences of the human ABLIM2 and ABLIM1 proteins showed that the number and arrangement of domains (four LIM-domains in the N-end region and the C-end VHP-domain) were similar [2].

Analytical, diagnostic and therapeutic context of ABLIM1

Radiation hybrid mapping placed LIMAB1 in a 37-cR interval between markers D10S554 and D10S2390 [1].

References

Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers. Kim, A.C., Peters, L.L., Knoll, J.H., Van Huffel, C., Ciciotte, S.L., Kleyn, P.W., Chishti, A.H. Genomics (1997) [Pubmed]
Genomic organisation and tissue specific expression of ABLIM2 gene in human, mouse and rat. Klimov, E., Rud'ko, O., Rakhmanaliev, E., Sulimova, G. Biochim. Biophys. Acta (2005) [Pubmed]

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ABLIM1	Bos taurus
ABLIM1	Canis lupus familiaris
ablim1a	Danio rerio
ABLIM1	Gallus gallus
Ablim1	Mus musculus
ABLIM1	Pan troglodytes
Ablim1	Rattus norvegicus
LOC100170541	Xenopus (Silurana) tropicalis

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