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Gene Review: 

Prosbeta6  -  Proteasome beta6 subunit

Drosophila melanogaster

Synonyms: Beta-6, CG4097, DTS-5, DTS5, Dmel\CG4097, ...
 
 
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High impact information on Pros26

  • Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit [1].
  • Two dominant temperature-sensitive (DTS) lethal mutants of Drosophila melanogaster are Pros26(1) and Prosbeta2(1), previously known as DTS5 and DTS7 [2].
  • In an effort to isolate additional proteasome-related mutants a screen for dominant suppressors of Pros26(1) was carried out, resulting in the identification of Pros25(SuDTS) [originally called Su(DTS)], a missense mutation in the gene encoding the 20S proteasome alpha2 subunit [2].
 

Biological context of Pros26

  • At nonpermissive temperature (29 degrees C), heterozygotes (DTS5/+ and DTS7/+) develop normally until metamorphosis; pupae fail to mature and die before eclosion [3].
 

Associations of Pros26 with chemical compounds

  • Two dominant temperature-sensitive (DTS) Drosophila mutants are missense mutations of proteasome genes encoding beta-type subunits beta6/C5 (DTS5) and beta2/Z (DTS7) [3].

References

  1. Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit. Saville, K.J., Belote, J.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene. Neuburger, P.J., Saville, K.J., Zeng, J., Smyth, K.A., Belote, J.M. Genetics (2006) [Pubmed]
  3. Subunit compositions and catalytic properties of proteasomes from developmental temperature- sensitive mutants of Drosophila melanogaster. Covi, J.A., Belote, J.M., Mykles, D.L. Arch. Biochem. Biophys. (1999) [Pubmed]
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