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Gene Review

dpiA  -  two-component response regulator DpiA

Escherichia coli UTI89

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Disease relevance of dpiA

  • We identified a gene (dpiA, Destabilizer of Plasmid Inheritance) which, when overexpressed in Escherichia coli, destabilizes the inheritance of pSC101 and other iteron-containing plasmids as disparate as mini-F and RK6 but not the inheritance of P1, RSF1010 and ColD [1].
  • The dpiA and dpiB genes of Escherichia coli, which are orthologs of genes that regulate citrate uptake and utilization in Klebsiella pneumoniae, comprise a two-component signal transduction system that can modulate the replication of and destabilize the inheritance of pSC101 and certain other plasmids [2].


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