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Gene Review:

stk11 - serine/threonine kinase 11

Xenopus laevis

Su, J.Y. et al., Hemminki, A. et al.

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High impact information on XEEK1

This previously identified but unmapped gene, LKB1, has strong homology to a cytoplasmic Xenopus serine/threonine protein kinase XEEK1, and weaker similarity to many other protein kinases [1].
This site is distinct from the conserved threonine (Thr-215 in XEEK1) present in the protein kinase activation loop that is the site of autophosphorylation for many protein kinases [2].
An immunoprecipitate of oocyte/egg extracts with anti-XEEK1 serum contains a protein of approximately 155 kDa that may be a substrate and/or a regulatory component of the kinase [2].
XEEK1 is a substrate for the cyclic AMP-dependent protein kinase both in vitro and in vivo, suggesting a possible mode of regulation of XEEK1 [2].

Associations of XEEK1 with chemical compounds

Bacterially expressed XEEK1 migrates at 57 kDa upon polyacrylamide gel electrophoresis analysis, and a XEEK1-specific antibody recognizes a protein of 57 kDa in Xenopus oocyte and egg extracts [2].

References

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Hemminki, A., Markie, D., Tomlinson, I., Avizienyte, E., Roth, S., Loukola, A., Bignell, G., Warren, W., Aminoff, M., Höglund, P., Järvinen, H., Kristo, P., Pelin, K., Ridanpää, M., Salovaara, R., Toro, T., Bodmer, W., Olschwang, S., Olsen, A.S., Stratton, M.R., de la Chapelle, A., Aaltonen, L.A. Nature (1998) [Pubmed]
Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos. Su, J.Y., Erikson, E., Maller, J.L. J. Biol. Chem. (1996) [Pubmed]

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