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Gene Review

fgf20  -  fibroblast growth factor 20

Xenopus laevis

Synonyms: xfgf-20, xfgf20
 
 
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High impact information on XFGF-20

  • Both XFGF20 and Xdkk-1 are expressed early in Xenopus embryogenesis under the control of the Wnt signaling pathway [1].
  • These results suggest that correct expression of XFGF-20 during gastrulation is required for the formation of normal head structures in Xenopus laevis during embryogenesis and that expression of the Xbra gene mediates this phenomenon [2].
  • The cDNA for a novel member of the FGF family (XFGF-20) was isolated from a Xenopus cDNA library prepared at the tailbud stage using as a probe the product of degenerate PCR performed with primers based on mammalian FGF-9s [2].
  • XFGF-20 mRNA was expressed only zygotically in embryos at and after the blastula stage, but it was also specifically expressed in the stomach and testis of adults [2].

References

  1. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. Chamorro, M.N., Schwartz, D.R., Vonica, A., Brivanlou, A.H., Cho, K.R., Varmus, H.E. EMBO J. (2005) [Pubmed]
  2. Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis. Koga, C., Adati, N., Nakata, K., Mikoshiba, K., Furuhata, Y., Sato, S., Tei, H., Sakaki, Y., Kurokawa, T., Shiokawa, K., Yokoyama, K.K. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
 
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