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Gene Review

leuB  -  3-isopropylmalate dehydrogenase, NAD(+)...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0075, JW5807
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Disease relevance of leuB


High impact information on leuB


Biological context of leuB


Associations of leuB with chemical compounds

  • Activity of the leuB promoter was significantly reduced when leucine was present in the growth medium [5].

Analytical, diagnostic and therapeutic context of leuB


  1. A new Thermus-Escherichia coli shuttle integration vector system. Tamakoshi, M., Uchida, M., Tanabe, K., Fukuyama, S., Yamagishi, A., Oshima, T. J. Bacteriol. (1997) [Pubmed]
  2. Cloning in Escherichia coli of genes involved in the synthesis of proline and leucine in Desulfovibrio desulfuricans Norway. Fons, M., Cami, B., Patte, J.C., Chippaux, M. Mol. Gen. Genet. (1987) [Pubmed]
  3. Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus. Wallon, G., Kryger, G., Lovett, S.T., Oshima, T., Ringe, D., Petsko, G.A. J. Mol. Biol. (1997) [Pubmed]
  4. Screening of a mutant plasmid with high expression efficiency of GC-rich leuB gene of an extreme thermophile, Thermus thermophilus, in Escherichia coli. Suzuki, T., Tanaka, Y., Ishida, M., Ishizuka, M., Yamagishi, A., Oshima, T. J. Biochem. (1997) [Pubmed]
  5. Analysis of the leuB gene from Corynebacterium glutamicum. Pátek, M., Hochmannová, J., Jelínková, M., Nesvera, J., Eggeling, L. Appl. Microbiol. Biotechnol. (1998) [Pubmed]
  6. Urea-induced unfolding and conformational stability of 3-isopropylmalate dehydrogenase from the Thermophile thermus thermophilus and its mesophilic counterpart from Escherichia coli. Motono, C., Yamagishi, A., Oshima, T. Biochemistry (1999) [Pubmed]
  7. Cloning and sequence analysis of the LEU2 homologue gene from Pichia anomala. De la Rosa, J.M., Pérez, J.A., Gutiérrez, F., González, J.M., Ruiz, T., Rodríguez, L. Yeast (2001) [Pubmed]
  8. Further improvement of the thermal stability of a partially stabilized Bacillus subtilis 3-isopropylmalate dehydrogenase variant by random and site-directed mutagenesis. Akanuma, S., Yamagishi, A., Tanaka, N., Oshima, T. Eur. J. Biochem. (1999) [Pubmed]
  9. Highly efficient production of enzymes of an extreme thermophile, Thermus thermophilus: A practical method to overexpress GC-rich genes in Escherichia coli. Ishida, M., Yoshida, M., Oshima, T. Extremophiles (1997) [Pubmed]
  10. Cloning and analysis of the leuB gene of Leptospira interrogans serovar pomona. Ding, M., Yelton, D.B. J. Gen. Microbiol. (1993) [Pubmed]
  11. Molecular cloning of the leuB genes from Mycobacterium bovis BCG and Mycobacterium tuberculosis. Han, M.Y., Son, M.Y., Lee, S.H., Kim, J.K., Huh, J.S., Kim, J.H., Choe, I.S., Chung, T.W., Choe, Y.K. Biochem. Mol. Biol. Int. (1997) [Pubmed]
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