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Gene Review:

gbx2.1 - gastrulation brain homeobox 2, gene 1

Xenopus laevis

Synonyms: Gbx2, XGBX-2, gbx2b

Lauberth, S.M. et al., Tour, E. et al., Tour, E. et al.

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High impact information on Gbx2b

The border between the transcription domains of Otx2 and Gbx2 is the earliest known marker of the region where the midbrain/hindbrain boundary (MHB) organizer will develop [1].
Gbx2 homeobox genes are important for formation and function of the midbrain/hindbrain boundary, namely the isthmic organizer [2].

Associations of Gbx2b with chemical compounds

We demonstrate that protein kinase C phosphorylates serine 2 of the Sall1 repression motif and reveal that a phosphomimetic mutation of serine 2 disrupts the ability of Sall1 to repress Gbx2 in cell culture and Xenopus embryos [3].

References

Gbx2 interacts with Otx2 and patterns the anterior-posterior axis during gastrulation in Xenopus. Tour, E., Pillemer, G., Gruenbaum, Y., Fainsod, A. Mech. Dev. (2002) [Pubmed]
The two Xenopus Gbx2 genes exhibit similar, but not identical expression patterns and can affect head formation. Tour, E., Pillemer, G., Gruenbaum, Y., Fainsod, A. FEBS Lett. (2001) [Pubmed]
A phosphomimetic mutation in the Sall1 repression motif disrupts recruitment of the nucleosome remodeling and deacetylase complex and repression of Gbx2. Lauberth, S.M., Bilyeu, A.C., Firulli, B.A., Kroll, K.L., Rauchman, M. J. Biol. Chem. (2007) [Pubmed]

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