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Gene Review:

fgf8 - fibroblast growth factor 8 (androgen-induced)

Xenopus laevis

Synonyms: AIGF, FGF-8, Xfgf-8, Xfgf8, fgf-8b, ...

Fletcher, R.B. et al., Shim, S. et al.

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High impact information on FGF-8b

Using a loss-of-function approach, we demonstrate that FGF8 is necessary for proper gastrulation and formation of mesoderm and that FGF8b is the predominant FGF8 spliceform involved in early mesoderm development in Xenopus [1].
Furthermore, FGF8 signaling is necessary for proper posterior neural formation; loss of either FGF8a or a reduction in both FGF8a and FGF8b causes a reduction in the hindbrain and spinal cord domains [1].
The Xenopus FGF-8a and FGF-8b isoforms have been reported to be neural crest and neuronal inducers, respectively [2].

Anatomical context of FGF-8b

FGF8b is a potent mesoderm inducer, while FGF8a has little effect on the development of mesoderm [1].

References

FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in Xenopus. Fletcher, R.B., Baker, J.C., Harland, R.M. Development (2006) [Pubmed]
Isolation of Xenopus FGF-8b and comparison with FGF-8a. Shim, S., Bae, N., Park, S.Y., Kim, W.S., Han, J.K. Mol. Cells (2005) [Pubmed]

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