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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

rac3  -  ras-related C3 botulinum toxin substrate 3...

Xenopus laevis

 
 
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High impact information on RAC1

  • In addition, the expression of dominant-negative Rac1 inhibited neurite extension and blocked agrin-mediated growth-cone turning [1].
  • We show that the small GTPase Cdc42 is required for maintenance of active endogenous X-PAK2 in resting stage VI oocytes, whereas Rac1 is not involved in this regulation [2].
  • Irrespective of the manipulation that caused the malformations, coexpression of dominant-negative forms of either Rac1 or LIM kinase rescued the phenotypes [3].
  • We have undertaken the first detailed analysis of Rho GTPase function during vertebrate development by analyzing how RhoA and Rac1 control convergent extension of axial mesoderm during Xenopus gastrulation [4].
  • Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts [5].
 

Analytical, diagnostic and therapeutic context of RAC1

  • Immunocytochemistry and live imaging of paxillin-green fluorescent protein (GFP) showed that inhibiting Rac1 blocked point contact formation, whereas Rac1 overactivation produced small, unstable point contacts [5].

References

  1. Agrin regulates growth cone turning of Xenopus spinal motoneurons. Xu, X., Fu, A.K., Ip, F.C., Wu, C.P., Duan, S., Poo, M.M., Yuan, X.B., Ip, N.Y. Development (2005) [Pubmed]
  2. Regulation of Xenopus p21-activated kinase (X-PAK2) by Cdc42 and maturation-promoting factor controls Xenopus oocyte maturation. Cau, J., Faure, S., Vigneron, S., Labbé, J.C., Delsert, C., Morin, N. J. Biol. Chem. (2000) [Pubmed]
  3. p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus. Ciesiolka, M., Delvaeye, M., Van Imschoot, G., Verschuere, V., McCrea, P., van Roy, F., Vleminckx, K. J. Cell. Sci. (2004) [Pubmed]
  4. Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation. Tahinci, E., Symes, K. Dev. Biol. (2003) [Pubmed]
  5. Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts. Woo, S., Gomez, T.M. J. Neurosci. (2006) [Pubmed]
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