Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

brca1 - breast cancer 1, early onset

Xenopus laevis

Joukov, V. et al., Yoo, H.Y. et al., Shimizu, K. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on BRCA1

Conversely, neither phosphorylation of Claspin on these sites nor the presence of BRCA1 is necessary for activation of Chk1 in response to stalled replication forks [1].
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development [2].
Here we identify Xenopus Swift, a novel nuclear BRCT (BRCA1 C-terminal) domain protein that physically interacts with Smad2 via its BRCT domains [3].

Biological context of BRCA1

Depleting frog embryos of either BARD1 or BRCA1 led to similar and widely defective developmental phenotypes as well as depletion of the other polypeptide due to its decreased stability [2].

References

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Yoo, H.Y., Jeong, S.Y., Dunphy, W.G. Genes Dev. (2006) [Pubmed]
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Joukov, V., Chen, J., Fox, E.A., Green, J.B., Livingston, D.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling. Shimizu, K., Bourillot, P.Y., Nielsen, S.J., Zorn, A.M., Gurdon, J.B. Mol. Cell. Biol. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.