Gene Review:
BARD1 - BRCA1 associated RING domain 1
Homo sapiens
Synonyms:
BARD-1, BRCA1-associated RING domain protein 1
- Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers. Thai, T.H., Du, F., Tsan, J.T., Jin, Y., Phung, A., Spillman, M.A., Massa, H.F., Muller, C.Y., Ashfaq, R., Mathis, J.M., Miller, D.S., Trask, B.J., Baer, R., Bowcock, A.M. Hum. Mol. Genet. (1998)
- Germline mutations of the BRCA1-associated ring domain (BARD1) gene in breast and breast/ovarian families negative for BRCA1 and BRCA2 alterations. Ghimenti, C., Sensi, E., Presciuttini, S., Brunetti, I.M., Conte, P., Bevilacqua, G., Caligo, M.A. Genes Chromosomes Cancer (2002)
- Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway. Spahn, L., Petermann, R., Siligan, C., Schmid, J.A., Aryee, D.N., Kovar, H. Cancer Res. (2002)
- Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. Wu, J.Y., Vlastos, A.T., Pelte, M.F., Caligo, M.A., Bianco, A., Krause, K.H., Laurent, G.J., Irminger-Finger, I. Int. J. Cancer (2006)
- BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential, and apoptosis. Tembe, V., Henderson, B.R. J. Biol. Chem. (2007)
- The neurology in Shakespeare. Fogan, L. Arch. Neurol. (1989)
- C R Bard Nursing Award. Breast self-examination: the personal touch. Williams, K. Community outlook. (1979)
- The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Kleiman, F.E., Manley, J.L. Cell (2001)
- Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Scully, R., Chen, J., Ochs, R.L., Keegan, K., Hoekstra, M., Feunteun, J., Livingston, D.M. Cell (1997)
- Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Kleiman, F.E., Manley, J.L. Science (1999)
- A side by side comparison of cytology and biomarkers for bladder cancer detection. Schroeder, G.L., Lorenzo-Gomez, M.F., Hautmann, S.H., Friedrich, M.G., Ekici, S., Huland, H., Lokeshwar, V. J. Urol. (2004)
- Multicenter study of the feasibility and safety of using the memotherm carotid arterial stent for extracranial carotid artery stenosis. Qureshi, A.I., Suri, M.F., New, G., Wadsworth, D.C., Dulin, J., Hopkins, L.N. J. Neurosurg. (2002)
- Venous air embolism through a Groshong catheter. Waggoner, S.E. Gynecol. Oncol. (1993)
- Long-term follow-up comparison of durasphere and contigen in the treatment of stress urinary incontinence. Andersen, R.C. Journal of lower genital tract disease. (2002)
- Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. Sato, K., Hayami, R., Wu, W., Nishikawa, T., Nishikawa, H., Okuda, Y., Ogata, H., Fukuda, M., Ohta, T. J. Biol. Chem. (2004)
- Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1. Meza, J.E., Brzovic, P.S., King, M.C., Klevit, R.E. J. Biol. Chem. (1999)
- Repression of the putative tumor suppressor gene Bard1 or expression of Notch4(int-3) oncogene subvert the morphogenetic properties of mammary epithelial cells. Soriano, J.V., Irminger-Finger, I., Uyttendaele, H., Vaudan, G., Kitajewski, J., Sappino, A.P., Montesano, R. Adv. Exp. Med. Biol. (2000)
- Identification and characterization of missense alterations in the BRCA1 associated RING domain (BARD1) gene in breast and ovarian cancer. Sauer, M.K., Andrulis, I.L. J. Med. Genet. (2005)
- BRCA1-dependent and independent functions of BARD1. Irminger-Finger, I., Leung, W.C. Int. J. Biochem. Cell Biol. (2002)
- BRCA1-independent ubiquitination of FANCD2. Vandenberg, C.J., Gergely, F., Ong, C.Y., Pace, P., Mallery, D.L., Hiom, K., Patel, K.J. Mol. Cell (2003)
- The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. Chiba, N., Parvin, J.D. Cancer Res. (2002)
- The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. Wu-Baer, F., Lagrazon, K., Yuan, W., Baer, R. J. Biol. Chem. (2003)
- Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a potential factor in the antitumoral response mediated by apoptotic bodies. Gautier, F., Irminger-Finger, I., Grégoire, M., Meflah, K., Harb, J. Cancer Res. (2000)
- BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions. Brzovic, P.S., Meza, J.E., King, M.C., Klevit, R.E. J. Biol. Chem. (2001)
- Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2. Hayami, R., Sato, K., Wu, W., Nishikawa, T., Hiroi, J., Ohtani-Kaneko, R., Fukuda, M., Ohta, T. Cancer Res. (2005)
- BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. Starita, L.M., Horwitz, A.A., Keogh, M.C., Ishioka, C., Parvin, J.D., Chiba, N. J. Biol. Chem. (2005)
- Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1. Rodriguez, J.A., Schüchner, S., Au, W.W., Fabbro, M., Henderson, B.R. Oncogene (2004)
- Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in breast carcinomas. Yoshikawa, K., Ogawa, T., Baer, R., Hemmi, H., Honda, K., Yamauchi, A., Inamoto, T., Ko, K., Yazumi, S., Motoda, H., Kodama, H., Noguchi, S., Gazdar, A.F., Yamaoka, Y., Takahashi, R. Int. J. Cancer (2000)
- BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. Fabbro, M., Savage, K., Hobson, K., Deans, A.J., Powell, S.N., McArthur, G.A., Khanna, K.K. J. Biol. Chem. (2004)
- Nuclear targeting and cell cycle regulatory function of human BARD1. Schüchner, S., Tembe, V., Rodriguez, J.A., Henderson, B.R. J. Biol. Chem. (2005)
- Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. Choudhury, A.D., Xu, H., Modi, A.P., Zhang, W., Ludwig, T., Baer, R. J. Biol. Chem. (2005)
- Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis. Huo, X., Hu, Z., Zhai, X., Wang, Y., Wang, S., Wang, X., Qin, J., Chen, W., Jin, G., Liu, J., Gao, J., Wei, Q., Wang, X., Shen, H. Breast Cancer Res. Treat. (2007)
- Needle muscle biopsy with the automatic Biopty instrument. Coté, A.M., Jiménez, L., Adelman, L.S., Munsat, T.L. Neurology (1992)