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Gene Review:

n-ras - African clawed frog N-ras

Xenopus laevis

Spevak, W. et al., Soto-Cruz, I. et al., Moreau, J. et al.

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High impact information on N-ras

Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats [1].
Moreover, overexpression of Xenopus N-ras in S. cerevisiae does not activate the RAS-cyclic AMP (cAMP) pathway; rather, it results in decreased levels of intracellular cAMP in both mutant cdc15 and wild-type cells [1].
Proto-oncogenes raf and the ras family, N-ras, H-ras and c-ral, gave the strongest hybridizations and the signals remained positive in high stringency wash conditions [2].
The K(B)-ras peptide inhibited insulin-dependent but not progesterone-dependent maturation, in contrast with the N-ras peptide which did not inhibit maturation significantly [3].

References

Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats. Spevak, W., Keiper, B.D., Stratowa, C., Castañón, M.J. Mol. Cell. Biol. (1993) [Pubmed]
Detection of proto-oncogenes in the genome of the amphibian Xenopus laevis. Moreau, J., Le Guellec, R., Leibovici, M., Couturier, A., Philippe, M., Mechali, M. Oncogene (1989) [Pubmed]
Effect of synthetic peptides representing the hypervariable region of p21ras on Xenopus laevis oocyte maturation. Soto-Cruz, I., Magee, A.I. Biochem. J. (1995) [Pubmed]

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