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Gene Review:

fruR - DNA-binding transcriptional regulator FruR

Escherichia coli UTI89

Ryu, S. et al., Cortay, J.C. et al.

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Disease relevance of fruR

The fruR gene of Escherichia coli, which encodes the regulatory protein FruR, was cloned in the pT7-5 expression vector so as to overproduce a protein tagged with 6 histidine residues [1].

High impact information on fruR

Consistent with the in vitro results, pts P0 transcription did not increase as much in cells grown in the presence of fructose or in fruR- mutant cells as in cells grown in the presence of glucose [2].

References

In vitro asymmetric binding of the pleiotropic regulatory protein, FruR, to the ace operator controlling glyoxylate shunt enzyme synthesis. Cortay, J.C., Nègre, D., Scarabel, M., Ramseier, T.M., Vartak, N.B., Reizer, J., Saier, M.H., Cozzone, A.J. J. Biol. Chem. (1994) [Pubmed]
Effect of the FruR regulator on transcription of the pts operon in Escherichia coli. Ryu, S., Ramseier, T.M., Michotey, V., Saier, M.H., Garges, S. J. Biol. Chem. (1995) [Pubmed]

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