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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

argG  -  argininosuccinate synthase

Escherichia coli UTI89

 
 
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Disease relevance of argG

 

High impact information on argG

  • We identified two new targets of this complex: argG, which encodes the arginosuccinate synthase involved in the arginine biosynthetic pathway, and metY, which encodes one of the two methionine tRNA initiators, tRNAf2Met [1].
  • A recombinant form of Escherichia coli argininosuccinate synthetase with a C-terminal polyhistidine affinity tag has been expressed, purified and subsequently crystallized using the hanging-drop vapour-diffusion technique [2].
 

Analytical, diagnostic and therapeutic context of argG

References

  1. Transcription regulation coupling of the divergent argG and metY promoters in Escherichia coli K-12. Krin, E., Laurent-Winter, C., Bertin, P.N., Danchin, A., Kolb, A. J. Bacteriol. (2003) [Pubmed]
  2. Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli argininosuccinate synthetase. Lemke, C., Yeung, M., Howell, P.L. Acta Crystallogr. D Biol. Crystallogr. (1999) [Pubmed]
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