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Gene Review

HCRTR2  -  hypocretin (orexin) receptor 2

Canis lupus familiaris

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Psychiatry related information on HCRTR2

  • In canine genetic narcolepsy, produced by a mutation of the Hcrtr2 gene, symptoms develop postnatally with symptom onset at 4 weeks of age and maximal symptom severity by 10-32 weeks of age [1].

High impact information on HCRTR2

  • We find that by 4 days after birth, Hcrtr2 mutants have significantly higher levels of Hcrt than normal age- and breed-matched dogs [1].


  1. Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers. John, J., Wu, M.F., Maidment, N.T., Lam, H.A., Boehmer, L.N., Patton, M., Siegel, J.M. J. Physiol. (Lond.) (2004) [Pubmed]
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