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Gene Review

npr-1  -  Protein NPR-1

Caenorhabditis elegans

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High impact information on npr-1

  • Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans [1].
  • Natural variation at the npr-1 neuropeptide receptor alters both food-sensing and O2-sensing circuits to reconfigure the salient features of the C. elegans environment [2].
  • Loss-of-function mutations in ahr-1 or its transcription partner aha-1 (ARNT) suppress aggregation behavior in npr-1-deficient animals [3].


  1. Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. Davies, A.G., Bettinger, J.C., Thiele, T.R., Judy, M.E., McIntire, S.L. Neuron (2004) [Pubmed]
  2. Experience-dependent modulation of C. elegans behavior by ambient oxygen. Cheung, B.H., Cohen, M., Rogers, C., Albayram, O., de Bono, M. Curr. Biol. (2005) [Pubmed]
  3. The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior. Qin, H., Zhai, Z., Powell-Coffman, J.A. Dev. Biol. (2006) [Pubmed]
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