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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hcrtr2  -  hypocretin (orexin) receptor 2

Rattus norvegicus

Synonyms: Hypocretin receptor type 2, Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R
 
 
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Disease relevance of Hcrtr2

  • Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins [1].
 

Psychiatry related information on Hcrtr2

 

High impact information on Hcrtr2

  • Moreover, orexin-A, which exerts its effects through orexin receptor type 1 and orexin receptor type 2 with similar potency, resulted in a significant increase in wakefulness duration by 17.1% (n = 6, P < 0.05), 184.0% (n = 6, P < 0.01) and 228.6% (n = 6, P < 0.01) at doses of 0.1, 1 and 10 nmol, respectively [2].
  • The effects of third ventricle intracerebroventricular (ICV) infusion of the novel orexin receptor type 2 selective agonist, [Ala11]orexin-B, on the sleep-wake cycle were investigated [2].
  • The subsets of infiltrating mononuclear cells were investigated using MoAbs against rat CD4+ T cell (W3/25), CD8+ T cell (CX8), B cell (OX33) and macrophage (OX42) [3].

References

  1. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu, Y., Miwa, Y., Yamanaka, A., Yada, T., Shibahara, M., Abe, Y., Sakurai, T., Goto, K. J. Pharmacol. Sci. (2003) [Pubmed]
  2. Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats. Akanmu, M.A., Honda, K. Brain Res. (2005) [Pubmed]
  3. Immunohistochemical characterization of infiltrating mononuclear cells in the rat heart with experimental autoimmune giant cell myocarditis. Kodama, M., Zhang, S., Hanawa, H., Shibata, A. Clin. Exp. Immunol. (1992) [Pubmed]
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