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Gene Review

HCRTR2  -  hypocretin (orexin) receptor 2

Homo sapiens

Synonyms: Hypocretin receptor type 2, OX2R, Orexin receptor type 2, Ox-2-R, Ox2-R, ...
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Disease relevance of HCRTR2


Psychiatry related information on HCRTR2


High impact information on HCRTR2

  • The risk of cluster headache (CH) is associated with the G-allele of the G1246A polymorphism in the hypocretin receptor 2 (HCRTR2) gene [5].
  • While the HCRTR2 1246G allele was significantly associated with CH in this group, treatment outcomes with triptans, oxygen, verapamil and corticosteroids remained unaffected [5].
  • Positional cloning of the gene responsible for a canine model of narcolepsy revealed that this disease is caused by mutations in hypocretin receptor type 2 [6].


  1. Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene. Schürks, M., Kurth, T., Geissler, I., Tessmann, G., Diener, H.C., Rosskopf, D. Neurology (2006) [Pubmed]
  2. Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B. Mazzocchi, G., Malendowicz, L.K., Aragona, F., Rebuffat, P., Gottardo, L., Nussdorfer, G.G. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  3. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., Li, R., Hungs, M., Pedrazzoli, M., Padigaru, M., Kucherlapati, M., Fan, J., Maki, R., Lammers, G.J., Bouras, C., Kucherlapati, R., Nishino, S., Mignot, E. Nat. Med. (2000) [Pubmed]
  4. Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Hara, J., Yanagisawa, M., Sakurai, T. Neurosci. Lett. (2005) [Pubmed]
  5. The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. Schürks, M., Kurth, T., Geissler, I., Tessmann, G., Diener, H.C., Rosskopf, D. Cephalalgia : an international journal of headache (2007) [Pubmed]
  6. Hypocretins/orexins as integrators of physiological information: lessons from mutant animals. de Lecea, L., Sutcliffe, J.G., Fabre, V. Neuropeptides (2002) [Pubmed]
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