Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

traJ - functional relaxosome complex initiator

Escherichia coli UTI89

Foster, T.J. et al., Gasson, M.J. et al., Bayer, M. et al.

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Disease relevance of traJ

Using the results, a tentative map of this region of the R factor was drawn: it was essentially similar to the analogous region of the E. coli K12 F factor, except that tet was located between traJ and traA [1].

High impact information on traJ

F-like plasmids require a number of genes for conjugation, including tra operon genes and genes traM and traJ, which lie outside the tra operon [2].

Biological context of traJ

All three R factors inhibited transfer of J-independent Flac elements, indicating that they act directly on one or more genes (or products) of the transfer operon, rather than directly via traJ [3].

References

Genetic analysis of deletions of R100-1 that are both transfer-deficient and tetracycline-sensitive. Foster, T.J., Willetts, N.S. J. Gen. Microbiol. (1976) [Pubmed]
Gene 19 of plasmid R1 is required for both efficient conjugative DNA transfer and bacteriophage R17 infection. Bayer, M., Eferl, R., Zellnig, G., Teferle, K., Dijkstra, A., Koraimann, G., Högenauer, G. J. Bacteriol. (1995) [Pubmed]
Five control systems preventing transfer of Escherichia coli K-12 sex factor F. Gasson, M.J., Willetts, N.S. J. Bacteriol. (1975) [Pubmed]

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