Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

BRG1 - BRG1 protein

Xenopus laevis

This record was replaced with 100335135.

Gelius, B. et al., Havas, K. et al.

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Disease relevance of BRG1

We find that the ability to distort DNA is shared by the yeast SWI/SNF complex, Xenopus Mi-2 complex, recombinant ISWI, and recombinant BRG1, suggesting that the generation of superhelical torsion represents a primary biomechanical activity shared by all Snf2p-related ATPase motors [1].

High impact information on BRG1

Indirect immunofluorescence microscopy on cryostat-sectioned oocytes revealed that BRG1, which is a subunit of the SWI/SNF chromatin remodeling complex, as well as RNA polymerase II and recombinantly expressed Xenopus nuclear factor 1-B, are all associated with the endogenous chromosomes and the chromatin fibers formed on injected DNA [2].

References

Generation of superhelical torsion by ATP-dependent chromatin remodeling activities. Havas, K., Flaus, A., Phelan, M., Kingston, R., Wade, P.A., Lilley, D.M., Owen-Hughes, T. Cell (2000) [Pubmed]
Glucocorticoid hormone-induced receptor localization to the chromatin fibers formed on injected DNA in Xenopus oocytes. Gelius, B., Wrange , O. Exp. Cell Res. (2001) [Pubmed]

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