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smarca5  -  SWI/SNF related, matrix associated, actin...

Xenopus laevis

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Disease relevance of ISWI

  • Inhibition of ISWI function results in aberrant eye development and the formation of cataracts [1].
  • We find that the ability to distort DNA is shared by the yeast SWI/SNF complex, Xenopus Mi-2 complex, recombinant ISWI, and recombinant BRG1, suggesting that the generation of superhelical torsion represents a primary biomechanical activity shared by all Snf2p-related ATPase motors [2].

High impact information on ISWI


Biological context of ISWI

  • These data suggest a critical role for ISWI chromatin remodeling complexes in neural development, including eye differentiation, in the Xenopus laevis embryo [1].
  • Expression of ISWI and its binding to chromatin during the cell cycle and early development [6].

Anatomical context of ISWI


Other interactions of ISWI


  1. Neural and eye-specific defects associated with loss of the Imitation Switch (ISWI) chromatin remodeler in Xenopus laevis. Dirscherl, S.S., Henry, J.J., Krebs, J.E. Mech. Dev. (2005) [Pubmed]
  2. Generation of superhelical torsion by ATP-dependent chromatin remodeling activities. Havas, K., Flaus, A., Phelan, M., Kingston, R., Wade, P.A., Lilley, D.M., Owen-Hughes, T. Cell (2000) [Pubmed]
  3. Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI. Kikyo, N., Wade, P.A., Guschin, D., Ge, H., Wolffe, A.P. Science (2000) [Pubmed]
  4. Critical role for the histone H4 N terminus in nucleosome remodeling by ISWI. Clapier, C.R., Längst, G., Corona, D.F., Becker, P.B., Nightingale, K.P. Mol. Cell. Biol. (2001) [Pubmed]
  5. ISWI remodeling complexes in Xenopus egg extracts: identification as major chromosomal components that are regulated by INCENP-aurora B. MacCallum, D.E., Losada, A., Kobayashi, R., Hirano, T. Mol. Biol. Cell (2002) [Pubmed]
  6. Expression of ISWI and its binding to chromatin during the cell cycle and early development. Demeret, C., Bocquet, S., Lemaítre, J.M., Françon, P., Méchali, M. J. Struct. Biol. (2002) [Pubmed]
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