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Gene Review:

PGB - progastricsin (pepsinogen C)

Canis lupus familiaris

Synonyms: PGC, PGNB

Brown, S.A. et al., Gassée, J.P. et al.

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Disease relevance of PGC

We conclude that although treatment of diabetic dogs with either lisinopril or TA-3090 results in differential effects on PGC; each produces a similar decrement in proteinuria [1].

High impact information on PGC

Treatment with lisinopril lowered the PGC to a mean value that was indistinguishable from that for nondiabetic dogs [1].
In contrast, diabetic dogs treated with TA-3090 had an elevated PGC [1].
AII increased PGC, the intracapillary hydrostatic pressure, but more at the efferent end of the capillaries [2].

Analytical, diagnostic and therapeutic context of PGC

Our results were compared to those obtained from the direct measurements of PGC, using micropuncture techniqles in hydropenic and plasma loaded rats [2].

References

Long-term effects of antihypertensive regimens on renal hemodynamics and proteinuria. Brown, S.A., Walton, C.L., Crawford, P., Bakris, G.L. Kidney Int. (1993) [Pubmed]
Determination of glomerular intracapillary and transcapillary pressure gradients from sieving data. 3. The effects of angiotensin II. Gassée, J.P., du Bois, R., Staroukine, M., Lambert, P.P. Pflugers Arch. (1976) [Pubmed]

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LOC611675	Canis lupus familiaris
LOC428272	Gallus gallus
pgc	Xenopus (Silurana) tropicalis
pgc	Xenopus (Silurana) tropicalis
mgc108380	Xenopus (Silurana) tropicalis

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