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Gene Review:

MED1 - Mediator complex subunit 1

Drosophila melanogaster

Synonyms: CG7162, Dmel\CG7162, FBgn0037109, Med1, Med1/SOP3/TRAP220, ...

Park, J.M. et al., Kim, T.W. et al., Sato, S. et al., Zakharova, N. et al., Ito, M. et al.

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High impact information on MED1

Here, we show that upon heat shock the Pol II-free form of Mediator is rapidly recruited to HSF binding sites [1].
Recruitment of the Mediator complex by transcriptional activators is usually the key step in transcriptional activation [2].
MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators [2].
We conclude that chromatin remodeling by p300 in vivo makes TRAP/Mediator effective in stimulating transcription [3].
Here we identify one of these proteins, encoded by the previously uncharacterized AK000411 open reading frame, as a new subunit of the mammalian Mediator complex [4].

Associations of MED1 with chemical compounds

The TRAP/SMCC/Mediator complex and thyroid hormone receptor function [5].

References

Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park, J.M., Werner, J., Kim, J.M., Lis, J.T., Kim, Y.J. Mol. Cell (2001) [Pubmed]
MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Kim, T.W., Kwon, Y.J., Kim, J.M., Song, Y.H., Kim, S.N., Kim, Y.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates. Zakharova, N., Lymar, E.S., Yang, E., Malik, S., Zhang, J.J., Roeder, R.G., Darnell, J.E. J. Biol. Chem. (2003) [Pubmed]
A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. Sato, S., Tomomori-Sato, C., Banks, C.A., Parmely, T.J., Sorokina, I., Brower, C.S., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (2003) [Pubmed]
The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Ito, M., Roeder, R.G. Trends Endocrinol. Metab. (2001) [Pubmed]

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