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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ASIP  -  agouti signaling protein

Bos taurus

 
 
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High impact information on AGOUTI

  • In wild-type mice, it is well known that Agouti is only expressed in skin where it controls the banded-hair phenotype [1].
  • Sustained inhibitory effect of Agouti Related Protein on the ACTH-induced cortisol production by bovine cultured adrenal cells [2].
  • The mean minimal transit time for blood in muscle capillaries (tc) was estimated in six species, spanning two orders of magnitude in body mass and aerobic capacity: horse, steer, dog, goat, fox and agouti [3].
  • Results were confirmed by sequencing the coding exons of the ASIP gene in 20 individuals [4].
  • The coat colour loci yielding information on genetic variation were: extension, agouti, spotting, brindle, dun dilution and colour sided [5].
 

Biological context of AGOUTI

  • Polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis was carried out in individuals of each Extension genotypes within the same breed in an attempt to identify variants in the three coding exons of the ASIP gene [4].

References

  1. Widespread expression of the bovine Agouti gene results from at least three alternative promoters. Girardot, M., Martin, J., Guibert, S., Leveziel, H., Julien, R., Oulmouden, A. Pigment Cell Res. (2005) [Pubmed]
  2. Sustained inhibitory effect of Agouti Related Protein on the ACTH-induced cortisol production by bovine cultured adrenal cells. Doghman, M., Delagrange, P., Berthelon, M.C., Durand, P., Naville, D., Bégeot, M. Regul. Pept. (2005) [Pubmed]
  3. Capillary blood transit time in muscles in relation to body size and aerobic capacity. Kayar, S.R., Hoppeler, H., Jones, J.H., Longworth, K., Armstrong, R.B., Laughlin, M.H., Lindstedt, S.L., Bicudo, J.E., Groebe, K., Taylor, C.R. J. Exp. Biol. (1994) [Pubmed]
  4. The coding sequence of the ASIP gene is identical in nine wild-type coloured cattle breeds. Royo, L.J., Alvarez, I., Fernández, I., Arranz, J.J., Gómez, E., Goyache, F. J. Anim. Breed. Genet. (2005) [Pubmed]
  5. Frequencies of genes for coat colour and horns in Nordic cattle breeds. Kantanen, J., Olsaker, I., Brusgaard, K., Eythorsdottir, E., Holm, L.E., Lien, S., Danell, B., Adalsteinsson, S. Genet. Sel. Evol. (2000) [Pubmed]
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