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Gene Review

ren  -  renin

Danio rerio

Synonyms: SO:0000704
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High impact information on ren

  • Renin is a key enzyme in the renin-angiotensin system (RAS), a pathway which plays an important physiological role in blood pressure and electrolyte homeostasis [1].

Analytical, diagnostic and therapeutic context of ren

  • Comparative in situ hybridization analysis of wild-type and developmental mutants indicates that renin expression is first detected bilaterally in cells of the interrenal primordia at 24 h postfertilization, which subsequently migrate to lie adjacent to, but distinct from, the glomerulus of the developing pronephric kidney [1].


  1. Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish. Liang, P., Jones, C.A., Bisgrove, B.W., Song, L., Glenn, S.T., Yost, H.J., Gross, K.W. Physiol. Genomics (2004) [Pubmed]
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