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Gene Review

REN  -  renin

Bos taurus

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Disease relevance of REN


Psychiatry related information on REN

  • It is concluded that some intrarenal functional or structural change induced by water deprivation sensitizes the renin-secreting mechanism to colloid osmotic stimuli [6].

High impact information on REN

  • Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells [7].
  • Taken together, our findings provide first evidence for a local control function of the endothelium on cAMP stimulated renin secretion from renal juxtaglomerular cells, which could in part be mediated by endothelin [7].
  • Matrix-assisted laser desorption ionization is used to obtain Fourier-transform ion cyclotron resonance mass spectra of model peptides (e.g., gramicidin S, angiotensin I, renin substrate, melittin, and bovine insulin) [8].
  • These data document the lack of any significant stimulatory influence of decreased pulse pressure on renin secretion in a chronic awake calf model [9].
  • Although renal blood flow decreased slightly from control (667 +/- 84 ml/min) during the nonpulsatile perfusion period (555 +/- 73 ml/min), renin secretion did not increase significantly from control (482 +/- 81 ng angiotensin I/ml per hr per min) during the bypass period (531 +/- 99) [9].

Chemical compound and disease context of REN


Biological context of REN

  • Insulin-like growth factor I alters renal function and stimulates renin secretion in late gestation fetal sheep [11].
  • The more potent inhibitors (IC50 = 20-50 nM) were found to be selective inhibitors for renin over porcine pepsin and bovine cathepsin D (little or no inhibition was observed at 10(-5) M) [12].
  • 6. Synthesis of prostaglandins by the kidney is important to mechanisms which control renin release and renal vascular resistance [13].
  • Local reduction of perfusion pressure in small arteries and arterioles by the injection of microspheres induced a short-lasting decrease in renal plasma flow and a transient stimulation of renin release [14].
  • The vasoconstriction induced by the crude renin substrate probably does not involve the AII receptors [14].

Anatomical context of REN


Associations of REN with chemical compounds

  • In the presence of endothelial cells both spontaneous and forskolin (10 microM) or isoproterenol (10 microM) stimulated renin release were markedly attenuated [7].
  • Catecholamines had a weak stimulating effect on aldosterone secretion and were potent stimulators of adrenal renin activity in cells and medium [15].
  • The results of this study therefore suggest that theophylline-stimulated renin release may be mediated through a prostaglandin pathway [17].
  • The addition of progesterone (the major steroid product of the MA-10 cells) did not induce a significant increase in renin activity [18].
  • The treatment of Leydig cell cultures with bovine LH (bLH), hCG, or with (Bu)2cAMP elicited a dose- and time-dependent induction of renin activity and a concomitant increase in steroid biosynthesis [18].

Regulatory relationships of REN


Other interactions of REN

  • Contrary to its effect on aldosterone, TGF beta 1 stimulates the synthesis and release of adrenal renin and prorenin [19].
  • Plasma renin concentration increased by 275 +/- 52% during infusion of IGF-I (P < 0.005) [11].
  • STUDY OBJECTIVE--The aim of the study was to investigate plasma concentrations of atrial natriuretic peptide, aldosterone, and renin during experimentally induced acute central venous congestion [21].
  • It inhibited bovine and rat trypsin, showed weak inhibition of bovine chymotrypsin and was inactive against rat chymotrypsin and bovine renin, kallikrein, thrombin and trypsinogen [22].

Analytical, diagnostic and therapeutic context of REN


  1. The conversion of corticosterone to aldosterone is the site of the oxygen sensitivity of the bovine adrenal zona glomerulosa. Brickner, R.C., Jankowski, B., Raff, H. Endocrinology (1992) [Pubmed]
  2. The three-dimensional structure of recombinant bovine chymosin at 2.3 A resolution. Gilliland, G.L., Winborne, E.L., Nachman, J., Wlodawer, A. Proteins (1990) [Pubmed]
  3. Prolonged pulseless perfusion in unanesthetized calves. Johnston, G.G., Hammill, F., Marzec, U., Gerard, D., Johansen, K., Dilley, R.B., Bernstein, E.F. Archives of surgery (Chicago, Ill. : 1960) (1976) [Pubmed]
  4. Generation of angiotensinogen by cultured neuroblastoma and glioma cells. Clemens, D.L., Clauser, E., Celio, M.R., Inagami, T. Brain Res. (1986) [Pubmed]
  5. Volume homeostasis in calves with artificial atria and ventricles. Westenfelder, C., Birch, F.M., Baranowski, R.L., Riebman, J.B., Olsen, D.B., Burns, G.L., Kablitz, C. Am. J. Physiol. (1990) [Pubmed]
  6. The effect of water deprivation on the osmotic release of renin. Carvalho, J.S. Kidney Int. (1982) [Pubmed]
  7. Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells. Kurtz, A., Kaissling, B., Busse, R., Baier, W. J. Clin. Invest. (1991) [Pubmed]
  8. Laser desorption studies of high mass biomolecules in Fourier-transform ion cyclotron resonance mass spectrometry. Solouki, T., Russell, D.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Renin secretion in the chronically perfused pulseless calf. Evidence for failure of stimulation by decreased pulse pressure. Shoor, P.M., Marzec, U.M., Griffith, L.D., Hammill, F.S., Dilley, R.B., Bernstein, E.F. Circ. Res. (1979) [Pubmed]
  10. Plasma renin activity and aldosterone concentration in sodium-depleted cattle following ACTH or metoclopramide injection. Riad, F., Giry, J., Barlet, J.P. Reproduction, nutrition, development. (1987) [Pubmed]
  11. Insulin-like growth factor I alters renal function and stimulates renin secretion in late gestation fetal sheep. Marsh, A.C., Gibson, K.J., Wu, J., Owens, P.C., Owens, J.A., Lumbers, E.R. J. Physiol. (Lond.) (2001) [Pubmed]
  12. New inhibitors of renin that contain novel phosphostatine Leu-Val replacements. Dellaria, J.F., Maki, R.G., Stein, H.H., Cohen, J., Whittern, D., Marsh, K., Hoffman, D.J., Plattner, J.J., Perun, T.J. J. Med. Chem. (1990) [Pubmed]
  13. Interactions of prostaglandins with the kallikrein-kinin and renin-angiotensin systems. McGiff, J.C. Clin. Sci. (1980) [Pubmed]
  14. Regulation of renin release and intrarenal formation of angiotensin. Studies in the isolated perfused rat kidney. Hofbauer, K.G., Zschiedrich, H., Gross, F. Clin. Exp. Pharmacol. Physiol. (1976) [Pubmed]
  15. Regulation of the adrenal renin angiotensin system in cultured bovine zona glomerulosa cells: effect of catecholamines. Gupta, P., Franco-Saenz, R., Mulrow, P.J. Endocrinology (1992) [Pubmed]
  16. Inhibitory effects of a tumor-promoting phorbol ester on luteinizing hormone-stimulated renin and prorenin production by cultured bovine theca cells. Brunswig-Spickenheier, B., Mukhopadhyay, A.K. Endocrinology (1990) [Pubmed]
  17. The effect of theophylline and cyclic adenosine 3',5'-monophosphate on renin release by afferent arterioles. Cannon, M.E., Twu, B.M., Yang, C.S., Hsu, C.H. J. Hypertens. (1989) [Pubmed]
  18. Induction of renin activity by gonadotropic hormones in cultured Leydig tumor cells. Pandey, K.N., Ascoli, M., Inagami, T. Endocrinology (1985) [Pubmed]
  19. Transforming growth factor-beta 1 inhibits aldosterone and stimulates adrenal renin in cultured bovine zona glomerulosa cells. Gupta, P., Franco-Saenz, R., Gentry, L.E., Mulrow, P.J. Endocrinology (1992) [Pubmed]
  20. Effects of tumor necrosis factor-alpha on luteinizing hormone-stimulated prorenin production by bovine ovarian thecal cells in vitro. Brunswig-Spickenheier, B., Mukhopadhyay, A.K. Endocrinology (1993) [Pubmed]
  21. Action of endogenous atrial natriuretic peptide in calves with experimental acute central venous congestion and low cardiac output. Rokitansky, A.M., Losert, U.M., Trubel, W., Wieselthaler, G., Krausler, S., Shreiner, W., Buxbaum, P., Vierhapper, H., Waldhäusl, W.K., Wolner, E. Cardiovasc. Res. (1990) [Pubmed]
  22. Isolation and properties of bovine colostral trypsin inhibitor. Piñeiro, A., Brock, J.H., Esparza, I. Ann. Rech. Vet. (1978) [Pubmed]
  23. Renin expression by vascular endothelial cells in culture. Lilly, L.S., Pratt, R.E., Alexander, R.W., Larson, D.M., Ellison, K.E., Gimbrone, M.A., Dzau, V.J. Circ. Res. (1985) [Pubmed]
  24. Brain renin from bovine anterior pituitary. Isolation and properties. Hirose, S., Ohsawa, T., Inagami, T., Murakami, K. J. Biol. Chem. (1982) [Pubmed]
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