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Gene Review:

UbcD6 - Ubiquitin conjugating enzyme

Drosophila melanogaster

Synonyms: BcDNA:RE56673, CG2013, Dhr6, Dmel\CG2013, RAD6, ...

Phuong Thao, D.T. et al., Takeda, K. et al., Yamaguchi, T. et al., Nascimento, R.M. et al., Oh, C.E. et al.

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Disease relevance of UbcD6

UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome [1].

High impact information on UbcD6

Here we show that the fission yeast ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1 are responsible for nuclear enrichment of proteasome through the function of Cut8, a nuclear envelope protein [2].
bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog [3].
SKPa is component of a Drosophila SCF complex that functions in combination with the ubiquitin-conjugating enzyme UbcD1. skpA null mutation results in centrosome overduplication, unusual chromatin condensation, defective endoreduplication and cell-cycle progression [4].

Biological context of UbcD6

The amino acid sequence showed 80% identity with the Drosophila's bendless gene product (ubiquitin-conjugating enzyme E2) [5].

References

UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome. Nascimento, R.M., Otto, P.A., de Brouwer, A.P., Vianna-Morgante, A.M. Am. J. Hum. Genet. (2006) [Pubmed]
Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. Takeda, K., Yanagida, M. Cell (2005) [Pubmed]
bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog. Oh, C.E., McMahon, R., Benzer, S., Tanouye, M.A. J. Neurosci. (1994) [Pubmed]
Identification of the Drosophila skpA gene as a novel target of the transcription factor DREF. Phuong Thao, D.T., Ida, H., Yoshida, H., Yamaguchi, M. Exp. Cell Res. (2006) [Pubmed]
Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. Yamaguchi, T., Kim, N.S., Sekine, S., Seino, H., Osaka, F., Yamao, F., Kato, S. J. Biochem. (1996) [Pubmed]

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AgaP_AGAP003857	Anopheles gambiae str. PEST
UBC3	Arabidopsis thaliana
zgc:55512	Danio rerio

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