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Gene Review

skpA  -  CG16983 gene product from transcript...

Drosophila melanogaster

Synonyms: CG16983, Dmel\CG16983, EG:115C2.4, SKP1, SKPA, ...
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High impact information on skpA

  • Using a genetic modifier screen, we identified four enhancers of grim-reaper-induced apoptosis that all regulate ubiquitination processes: uba-1, skpA, fat facets (faf), and morgue [1].
  • In cultured cells, inhibition of SkpA and Slimb via RNAi increases levels of both the full-length Relish protein and the processed Rel-homology domain [2].
  • However, centrosome overduplication still occurs in skpA-; cycE- mutant animals, demonstrating that high cyclin E levels are not necessary for centrosome overduplication [3].
  • Lethal skpA null mutants exhibit dramatic centrosome overduplication and additional defects in chromatin condensation, cell cycle progression and endoreduplication [3].
  • Thus both luciferase transient expression assays in cultured Drosophila S2 cells using skpA promoter-luciferase fusion plasmids and anti-lacZ immunostaining of various tissues from transgenic third instar larvae carrying the skpA promoter-lacZ fusion genes provided supportive evidence [4].

Biological context of skpA

  • Knockdown of DREF in some tissues where SKPa distribution is well known almost completely abrogated the skpA gene expression [4].


  1. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Wing, J.P., Schreader, B.A., Yokokura, T., Wang, Y., Andrews, P.S., Huseinovic, N., Dong, C.K., Ogdahl, J.L., Schwartz, L.M., White, K., Nambu, J.R. Nat. Cell Biol. (2002) [Pubmed]
  2. A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. Khush, R.S., Cornwell, W.D., Uram, J.N., Lemaitre, B. Curr. Biol. (2002) [Pubmed]
  3. Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. Murphy, T.D. J. Cell. Sci. (2003) [Pubmed]
  4. Identification of the Drosophila skpA gene as a novel target of the transcription factor DREF. Phuong Thao, D.T., Ida, H., Yoshida, H., Yamaguchi, M. Exp. Cell Res. (2006) [Pubmed]
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