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Gene Review:

LRP2 - low density lipoprotein receptor-related...

Sus scrofa

Stefansson, S. et al., Ranganathan, S. et al., Chowdhary, B.P. et al.

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High impact information on LRP2

The results indicate that LRP-2 binds SVS-II and can mediate its endocytosis leading to lysosomal degradation [1].
The low density lipoprotein receptor-related protein-2/megalin (LRP-2) is an endocytic receptor that is expressed on the apical surfaces of epithelial cells lining specific regions of the male and female reproductive tracts [1].
Using a series of recombinant subfragments of SVS-II, the LRP-2 binding site was mapped to a stretch of repeated 13-residue modules located in the central portion of the SVS-II polypeptide [1].
A low level of LDL endocytosis existed that was likely mediated by LDLR since it could not be inhibited by LRP-2 antibodies, but was inhibited by excess LDL, receptor-associated protein, or apoB100 antibody [2].
In cell assays, LRP-2 antibodies blocked the elevated 125I-LDL internalization and degradation observed in the retinoic acid/dibutyryl cyclic AMP-treated F9 cells [2].

Biological context of LRP2

In situ hybridization mapping of a 500-kDa calcium-sensing protein gene (LRP2) to human chromosome region 2q31-->q32.1 and porcine chromosome region 15q22-->q24 [3].
The results indicate that LRP-2 can function to mediate cellular endocytosis of LDL, leading to its degradation [2].

Other interactions of LRP2

LRP-2 represents the second member of the LDLR family identified as functioning in the catabolism of LDL [2].

References

Identification of low density lipoprotein receptor-related protein-2/megalin as an endocytic receptor for seminal vesicle secretory protein II. Ranganathan, S., Knaak, C., Morales, C.R., Argraves, W.S. J. Biol. Chem. (1999) [Pubmed]
Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100. Stefansson, S., Chappell, D.A., Argraves, K.M., Strickland, D.K., Argraves, W.S. J. Biol. Chem. (1995) [Pubmed]
In situ hybridization mapping of a 500-kDa calcium-sensing protein gene (LRP2) to human chromosome region 2q31-->q32.1 and porcine chromosome region 15q22-->q24. Chowdhary, B.P., Lundgren, S., Johansson, M., Hjälm, G., Akerström, G., Gustavsson, I., Rask, L. Cytogenet. Cell Genet. (1995) [Pubmed]

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