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Gene Review:

GAL4 - Gal 4

Gallus gallus

Nakai, A. et al., Starczynowski, D.T. et al., Uchikawa, M. et al., Mutskov, V. et al., Smith, S.E. et al.

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High impact information on GAL4

Nucleosomes containing one or five GAL4 binding sites were reconstituted with hypoacetylated or hyperacetylated core histones [1].
HSF exhibits the properties of a transcriptional activator, as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4-HSF3 protein on a GAL4 reporter construct [2].
In contrast, mutation of Ser471 to a phosphorylation mimetic aspartate residue impaired REL's transforming ability, even though it increased REL's inherent transactivation ability as a GAL4-fusion protein [3].
C-terminal domains of SOX21 and SOX14 proteins function as strong and weak repression domains, respectively, when linked to the GAL4 DNA binding domain [4].

Analytical, diagnostic and therapeutic context of GAL4

Functional dissection of AP-1 transcription factors using the Gal4 adaptor assay [5].

References

Persistent interactions of core histone tails with nucleosomal DNA following acetylation and transcription factor binding. Mutskov, V., Gerber, D., Angelov, D., Ausio, J., Workman, J., Dimitrov, S. Mol. Cell. Biol. (1998) [Pubmed]
The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Nakai, A., Kawazoe, Y., Tanabe, M., Nagata, K., Morimoto, R.I. Mol. Cell. Biol. (1995) [Pubmed]
Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. Starczynowski, D.T., Reynolds, J.G., Gilmore, T.D. Oncogene (2005) [Pubmed]
Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken. Uchikawa, M., Kamachi, Y., Kondoh, H. Mech. Dev. (1999) [Pubmed]
Functional dissection of AP-1 transcription factors using the Gal4 adaptor assay. Smith, S.E., Bohmann, D. Cell Growth Differ. (1992) [Pubmed]

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