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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SOX14  -  SRY (sex determining region Y)-box 14

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High impact information on SOX14

  • In vivo grafting of chick notochord tissue to ectopic positions adjacent to the developing spinal cord altered the expression domain of Sox14 [1].
  • Sox14 marks a subset of interneurons at a defined dorsoventral position adjacent to ventral motor neurons in the spinal cord [1].
  • C-terminal domains of SOX21 and SOX14 proteins function as strong and weak repression domains, respectively, when linked to the GAL4 DNA binding domain [2].
 

Anatomical context of SOX14

  • Sox14 expression is restricted to a limited population of neurons in the developing brain and spinal cord of both species [1].

References

  1. The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog. Hargrave, M., Karunaratne, A., Cox, L., Wood, S., Koopman, P., Yamada, T. Dev. Biol. (2000) [Pubmed]
  2. Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken. Uchikawa, M., Kamachi, Y., Kondoh, H. Mech. Dev. (1999) [Pubmed]
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